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ARFGEF2 Antikörper (AA 761-860) (FITC)

ARFGEF2 Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal FITC
Produktnummer ABIN1393424
  • Target Alle ARFGEF2 Antikörper anzeigen
    ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))
    Bindungsspezifität
    • 14
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 761-860
    Reaktivität
    • 43
    • 19
    • 12
    Human
    Wirt
    • 43
    Kaninchen
    Klonalität
    • 43
    Polyklonal
    Konjugat
    • 12
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ARFGEF2 Antikörper ist konjugiert mit FITC
    Applikation
    • 23
    • 12
    • 12
    • 12
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ARFGEF2/BIG2
    Isotyp
    IgG
    Top Product
    Discover our top product ARFGEF2 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    ARFGEF2 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2))
    Andere Bezeichnung
    ARFGEF2/BIG2 (ARFGEF2 Produkte)
    Synonyme
    AI463430 antikoerper, AW493672 antikoerper, BIG2 antikoerper, E230011G24Rik antikoerper, Big2 antikoerper, PVNH2 antikoerper, dJ1164I10.1 antikoerper, ADP ribosylation factor guanine nucleotide exchange factor 2 antikoerper, ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) antikoerper, ARFGEF2 antikoerper, Arfgef2 antikoerper
    Hintergrund

    Synonyms: ADP ribosylation factor guanine nucleotide exchange factor 2 brefeldin A inhibited, ADP ribosylation factor guanine nucleotide exchange factor 2, ARFGEF 2, ARFGEF2, ARFGEP2, BIG 2, BIG2, Brefeldin A inhibited 2, Brefeldin A inhibited GEP 2, Brefeldin A inhibited guanine nucleotide exchange protein 2, dJ1164I10.1, BIG2_HUMAN.

    Background: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects golgi structure, and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

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