Senataxin (SETX) Antikörper (Alexa Fluor 555)

Details zu Produkt Nr. ABIN1392779, Anbieter: Anmelden zum Anzeigen
Antigen
  • ALS4
  • SETX
  • wu:fj92h09
  • AOA2
  • SCAR1
  • bA479K20.2
  • Als4
  • Sen1
  • AW060766
  • mKIAA0625
  • A130090N03
  • A930037J23Rik
  • RGD1565575
  • senataxin
  • SETX
  • setx
  • Setx
Reaktivität
Human, Maus, Ratte (Rattus)
103
14
14
1
Wirt
Kaninchen
62
41
Klonalität
Polyklonal
Konjugat
Alexa Fluor 555
6
6
6
6
5
5
5
5
5
5
4
4
4
4
2
2
2
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
50
49
47
34
16
14
12
6
4
1
1
1
Optionen
Hersteller
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Immunogen KLH conjugated synthetic peptide derived from human Senataxin
Isotyp IgG
Reinigung Purified by Protein A.
Andere Bezeichnung Senataxin/Setx (SETX Antibody Abstract)
Hintergrund

Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).

Subcellular location: Cytoplasm, Nucleus

Synonyms: ALS4, AOA2, SCAR1, bA479K20.2, Probable helicase senataxin, Amyotrophic lateral sclerosis 4 protein, SEN1 homolog, Senataxin, SETX, KIAA0625

Gen-ID 23064
UniProt Q7Z333
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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