PIRT Antikörper (AA 51-137) (Alexa Fluor 488)

Produktnummer ABIN1392370

Produktdetails anti-PIRT Antikörper (Alexa Fluor 488)

Target: PIRT (Phosphoinositide-Interacting Regulator of Transient Receptor Potential Channels (PIRT))

Bindungsspezifität: AA 51-137

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIRT Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PIRT

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu PIRT

Target: PIRT (Phosphoinositide-Interacting Regulator of Transient Receptor Potential Channels (PIRT))

Andere Bezeichnung: PIRT (PIRT Produkte)

Synonyme: A530088H08Rik antikoerper, RGD1565284 antikoerper, phosphoinositide interacting regulator of transient receptor potential channels antikoerper, phosphoinositide-interacting regulator of transient receptor potential channels antikoerper, PIRT antikoerper, Pirt antikoerper

Hintergrund:

Synonyms: hCG_1776018, Phosphoinositide interacting regulator of transient receptor potential channels , Phosphoinositide-interacting protein, Pirt, PIRT_HUMAN.

Background: PIRT is a 137 amino acid multi-pass membrane protein. Highly conserved among vertebrates, PIRT consists of two transmembrane domains and one putative C-terminal phosphoinositide-binding domain. Although PIRT is expressed in peripheral nervous system, with highest levels in dorsal root ganglion and trigeminal neurons, and lowest levels in sympathetic and enteric neurons, it is not expressed in spinal cord. PIRT is a required component of the VR1 complex, which positively regulates VR1, a sensor of both noxious heat and capsaicin. Correspondingly, PIRT knockout results in impaired responses to noxious heat and capsaicin exposure, while VR1 remains unaltered. The gene that encodes PIRT maps to human chromosome 17p13.1.