EN2 Antikörper (AA 281-333) (Biotin)

Produktnummer ABIN1391947

Produktdetails anti-EN2 Antikörper (Biotin)

Target: EN2 (Engrailed Homeobox 2 (EN2))

Bindungsspezifität: AA 281-333

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EN2 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Sheep,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EN2/Engrailed 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Referenzen für anti-EN2 Antikörper (Biotin) (ABIN1391947)

De Paoli, Gogalic, Sauer, Preininger, Pandha, Simpson, Horvath, Marquette: "Multiplatform Biomarker Discovery for Bladder Cancer Recurrence Diagnosis." in: Disease markers, Vol. 2016, pp. 4591910, (2016) (PubMed).

Details zu EN2

Target: EN2 (Engrailed Homeobox 2 (EN2))

Andere Bezeichnung: EN2/Engrailed 2 (EN2 Produkte)

Synonyme: EN2 antikoerper, en antikoerper, en2 antikoerper, BB131122 antikoerper, En-2 antikoerper, RGD1561842 antikoerper, Gg-En-2 antikoerper, engrailed homeobox 2 antikoerper, engrailed homeobox antikoerper, engrailed 2 antikoerper, EN2 antikoerper, en antikoerper, En2 antikoerper

Hintergrund:

Synonyms: Homeobox protein engrailed-2, Homeobox protein en-2, Hu-En-2, EN2

Background: The engrailed-2 gene, EN2, a murine homolog of the Drosophila homeobox gene engrailed (EN), is required for midbrain and cerebellum development and dorsal/ventral patterning of the limbs as well as apical ectodermal ridge formation. In Drosophila, the EN gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Human EN-1 and EN-2 are homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homologs, EN-1 and EN-2, produce different developmental defects that frequently are lethal. EN-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum. EN-1 and EN-2 regulate expression of a-synuclein, a gene that is genetically linked to Parkinson?s disease. During early brain development mouse EN-2 is expressed in a broad band across most of the mid-hindbrain region. EN-2 is also expressed in mouse myoblasts and has been assiciated with cerebellar hypoplasia.

Gen-ID: 2020

UniProt: P19622