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SORCS1 Antikörper (AA 561-660) (Alexa Fluor 488)

SORCS1 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 488
Produktnummer ABIN1390630
  • Target Alle SORCS1 Antikörper anzeigen
    SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1))
    Bindungsspezifität
    • 14
    • 10
    • 7
    • 5
    • 4
    AA 561-660
    Reaktivität
    • 35
    • 2
    Human
    Wirt
    • 35
    Kaninchen
    Klonalität
    • 35
    Polyklonal
    Konjugat
    • 8
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SORCS1 Antikörper ist konjugiert mit Alexa Fluor 488
    Applikation
    • 18
    • 17
    • 13
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SORCS1
    Isotyp
    IgG
    Top Product
    Discover our top product SORCS1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1))
    Andere Bezeichnung
    SORCS1 (SORCS1 Produkte)
    Synonyme
    hSorCS antikoerper, Sorcs antikoerper, mSorCS antikoerper, sortilin related VPS10 domain containing receptor 1 antikoerper, sortilin-related VPS10 domain containing receptor 1 antikoerper, SORCS1 antikoerper, Sorcs1 antikoerper
    Hintergrund

    Synonyms: SorCS 1, SORCS, SORCS-1, SORCS receptor 1, Sortilin related VPS10 domain containing receptor 1, VPS10 domain containing receptor SorCS1, VPS10 domain receptor protein SORCS 1, VPS10 domain receptor protein SORCS, VPS10 domain receptor protein SORCS1, VPS10 domain receptor SorCS, FLJ41758, FLJ43475, FLJ44957, hSorCS, OTTHUMP00000058855, SORC1_HUMAN.

    Background: There are three sorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, the homologous SorCS1 and SorCS2 genes and the SorCS3 gene are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS1 is a type 1 receptor containing a VPS10P domain and a leucine-rich domain. Alternative splicing of human SorCS1 results in four isoforms with different cytoplasmic tails and differential expression in tissues. Human SorCS1 is detected in fetal and infant brain and in fetal retina. Alternative splicing of murine SorCS1 also results in four isoforms. Murine isoform 1 is highly expressed in brain and at lower levels in heart, liver and kidney. It is detected in newborn mouse brain and in adult olfactory bulb and cerebral cortex. Murine isoform 2 is highly expressed in liver and at lower levels in heart, brain, kidney and testis.

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