PCYT1A Antikörper (AA 201-300) (AbBy Fluor® 488)

Produktnummer ABIN1390486

Produktdetails anti-PCYT1A Antikörper (AbBy Fluor® 488)

Target: PCYT1A (Phosphate Cytidylyltransferase 1, Choline, alpha (PCYT1A))

Bindungsspezifität: AA 201-300

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCYT1A Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PCYT1A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu PCYT1A

Target: PCYT1A (Phosphate Cytidylyltransferase 1, Choline, alpha (PCYT1A))

Andere Bezeichnung: PCYT1A (PCYT1A Produkte)

Hintergrund:

Synonyms: CCT A, CCT alpha, CCT-alpha, Choline phosphate cytidylyltransferase A, Choline-phosphate cytidylyltransferase A, CT A, CT antibody CTP:phosphocholine cytidylyltransferase A, CTPCT, PCY1A_HUMAN, PCYT1, Pcyt1a, Phosphate cytidylyltransferase 1 choline alpha, Phosphate cytidylyltransferase 1 choline alpha isoform, Phosphorylcholine transferase A.

Background: Increase in fetal surfactant synthesis and lung maturity is caused by the glucocorticoidal induction of enzymes required for phosphatidylcholine synthesis towards the end of gestation (1). The regulation of gestational age-dependent induction of phosphatidylcholine synthesis by glucocorticoids is still unclear (1). The rate-controlling enzyme in the phosphatidylcholine biosynthetic pathway is CTP-phosphocholine cytidylyltransferase A (CCT A) (24). In cultured eukaryotic cells, this enzyme is essential for survival (3). The alpha isoform is located in the nucleus and is regulated by reversible phosphorylation and membrane association (3). There is significant identity between the alpha-helical membrane-binding domains of CCT A and soybean oleosin (2). Expressed CCT A has lipid-dependent cytidylyltransferase activity (5). The gene which encodes CCT A maps to human chromosome 3q (4).