CREB3L3 Antikörper (AA 201-300) (Alexa Fluor 555)

Produktnummer ABIN1390097

Produktdetails anti-CREB3L3 Antikörper (Alexa Fluor 555)

Target: CREB3L3 (cAMP Responsive Element Binding Protein 3-Like 3 (CREB3L3))

Bindungsspezifität: AA 201-300

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CREB3L3 Antikörper ist konjugiert mit Alexa Fluor 555

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CREB-H

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CREB3L3

Target: CREB3L3 (cAMP Responsive Element Binding Protein 3-Like 3 (CREB3L3))

Andere Bezeichnung: CREB-H/CREB3L3 (CREB3L3 Produkte)

Synonyme: CREB-H antikoerper, CREBH antikoerper, BC010786 antikoerper, D10Bur1e antikoerper, creb3l3a antikoerper, creb3l3b antikoerper, si:dkey-110c1.2 antikoerper, wu:fc88h05 antikoerper, zgc:112279 antikoerper, cAMP responsive element binding protein 3 like 3 antikoerper, cAMP responsive element binding protein 3-like 3 antikoerper, cAMP responsive element binding protein 3-like 3a antikoerper, CREB3L3 antikoerper, Creb3l3 antikoerper, creb3l3a antikoerper

Hintergrund:

Synonyms: cAMP responsive element binding protein 3 like 3, cAMP responsive element-binding protein 3 like protein 3, CREB H, CREB/ATF family transcription factor, CREBH, Cyclic AMP responsive element binding protein 3 like protein 3, cAMP-responsive element-binding protein 3-like protein 3, HYST1481, MGC126553, MGC126557, Transcription factor CREB H, CR3L3_HUMAN.

Background: CREB3L3 is a 461 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticulum (ER) and, in response to ER stress, is cleaved and translocated to the nucleus. Expressed exclusively in liver, CREB3L3 functions as a transcription factor that, during ER stress, is thought to activate genes that are involved in both the unfolded protein response and the acute phase response (APR). Additionally, CREB3L3 is underexpressed in hepatocellular carcinoma, suggesting a possible role as a tumor suppressor. CREB3L3 functions as a dimer and contains one leucine zipper domain, a KDEL-like sequence and a bZIP domain, through which it conveys its DNA binding ability. Three isoforms of CREB3L3 exist due to alternative splicing events.

Pathways: Thyroid Hormone Synthesis