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LEFTY1 Antikörper (AA 51-150) (Alexa Fluor 555)

LEFTY1 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 555
Produktnummer ABIN1390079
  • Target Alle LEFTY1 Antikörper anzeigen
    LEFTY1 (Left-Right Determination Factor 1 (LEFTY1))
    Bindungsspezifität
    • 14
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reaktivität
    • 45
    • 12
    • 9
    Human
    Wirt
    • 51
    • 7
    • 1
    Kaninchen
    Klonalität
    • 52
    • 7
    Polyklonal
    Konjugat
    • 29
    • 10
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LEFTY1 Antikörper ist konjugiert mit Alexa Fluor 555
    Applikation
    • 40
    • 18
    • 17
    • 12
    • 12
    • 9
    • 9
    • 4
    • 4
    • 4
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Lefty
    Isotyp
    IgG
    Top Product
    Discover our top product LEFTY1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    LEFTY1 (Left-Right Determination Factor 1 (LEFTY1))
    Andere Bezeichnung
    Lefty (LEFTY1 Produkte)
    Synonyme
    atv antikoerper, cb73 antikoerper, antivin antikoerper, ik:tdsubc_2b12 antikoerper, xx:tdsubc_2b12 antikoerper, LEFTY1 antikoerper, AI450052 antikoerper, Ebaf antikoerper, Leftb antikoerper, Stra3 antikoerper, Tgfb4 antikoerper, lefty antikoerper, lefty-1 antikoerper, RGD1561867 antikoerper, LEFTB antikoerper, LEFTYB antikoerper, lefty1 antikoerper, signaling molecule lefty1 antikoerper, left-right determination factor 1 antikoerper, left right determination factor 1 antikoerper, lft1 antikoerper, lefty1 antikoerper, LOC699924 antikoerper, LEFTY1 antikoerper, LOC100408003 antikoerper, LOC100597378 antikoerper, Lefty1 antikoerper
    Hintergrund

    Synonyms: Protein lefty-1, AI450052, Ebaf, Left right determination factor 1, left right determination factor, Left right determination factor B, left-right determination factor, LEFT-RIGHT DETERMINATION FACTOR 1, LEFTY1, left-right determination, factor B, LEFT-RIGHT DETERMINATION, FACTOR B, LEFTY B, LEFTB, LEFTY 1, Lefty, lefty-1, LEFTY1, LEFTY1, MOUSE, HOMOLOG OF antibody, LEFTYB, Protein lefty-B, RGD1561867, Stimulated by retinoic acid gene 3 protein, STRA3, TGF beta 4, TGF-beta-4, Tgfb4, Transforming growth factor beta 4, Transforming growth factor beta-4.

    Background: During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28 kDa form induces MAPK activity.

    Gen-ID
    10637
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