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Proteoglycan 4 Antikörper (AA 1151-1250) (Alexa Fluor 350)

PRG4 Reaktivität: Maus, Ratte, Kaninchen WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 350
Produktnummer ABIN1389717
  • Target Alle Proteoglycan 4 (PRG4) Antikörper anzeigen
    Proteoglycan 4 (PRG4)
    Bindungsspezifität
    • 14
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1151-1250
    Reaktivität
    • 18
    • 18
    • 17
    • 14
    Maus, Ratte, Kaninchen
    Wirt
    • 28
    • 2
    • 1
    Kaninchen
    Klonalität
    • 29
    • 2
    Polyklonal
    Konjugat
    • 13
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Proteoglycan 4 Antikörper ist konjugiert mit Alexa Fluor 350
    Applikation
    • 26
    • 14
    • 12
    • 12
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus, Kaninchen, Ratte
    Homologie
    Human,Dog,Cow
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Lubricin/SZP
    Isotyp
    IgG
    Top Product
    Discover our top product PRG4 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Proteoglycan 4 (PRG4)
    Andere Bezeichnung
    Lubricin/SZP (PRG4 Produkte)
    Synonyme
    CACP antikoerper, HAPO antikoerper, JCAP antikoerper, MSF antikoerper, SZP antikoerper, bG174L6.2 antikoerper, lubricin antikoerper, prg4 antikoerper, si:dkey-97o5.3 antikoerper, zgc:122988 antikoerper, PRG4 antikoerper, DOL54 antikoerper, proteoglycan 4 antikoerper, proteoglycan 4b antikoerper, proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) antikoerper, PRG4 antikoerper, Prg4 antikoerper, prg4b antikoerper
    Hintergrund

    Synonyms: Superficial zone proteoglycan, articular superficial zone protein, bG174L6.2, CACP, camptodactyly arthropathy coxa vara pericarditis syndrome gene, FLJ32635, HAPO, Jacobs camptodactyly-arthropathy-pericarditis syndrome gene, JCAP, megakaryocyte stimulating factor, MSF, PRG 4, PRG4, proteoglycan 4, Proteoglycan4, Superficial zone proteoglycan, SZP.

    Background: Lubricin, also designated proteoglycan-4 or megakaryocyte stimulating factor, is important for boundary lubrication within articulating joints. It is a disulfide-linked homodimer (between Cysteine 1146 and Cysteine 1403) that is essential for protein cleavage. Lubricin inhibits synovial cell adhesion to the cartilage surface, but also prevents the deposition of proteins from synovial fluid onto cartilage. Lubricin is highly expressed in cartilage, liver and synovial tissue. Defects in the gene encoding for lubricin can cause Jakobs syndrome, also designated camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). CACP is an autosomal recessive disorder characterized by joint failure associated with noninflammatory synoviocyte hyperplasia and subinitimal fibrosis of the synovial capsule. Lubricin undergoes different levels of glycosylation and may be detected at varying molecular weights.

    Gen-ID
    10216
    UniProt
    Q92954
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