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PPARG Antikörper (pSer273)

PPARG Reaktivität: Human, Maus, Ratte, Schaf, Meerschweinchen WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1387919
  • Target Alle PPARG Antikörper anzeigen
    PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
    Bindungsspezifität
    • 21
    • 18
    • 16
    • 16
    • 15
    • 14
    • 9
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer273
    Reaktivität
    • 156
    • 108
    • 95
    • 33
    • 33
    • 24
    • 21
    • 20
    • 15
    • 10
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Schaf, Meerschweinchen
    Wirt
    • 148
    • 18
    • 3
    • 2
    Kaninchen
    Klonalität
    • 152
    • 20
    Polyklonal
    Konjugat
    • 85
    • 14
    • 11
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    Dieser PPARG Antikörper ist unkonjugiert
    Applikation
    • 154
    • 59
    • 55
    • 51
    • 51
    • 31
    • 21
    • 16
    • 13
    • 12
    • 7
    • 5
    • 5
    • 4
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Meerschweinchen, Human, Maus, Ratte, Schaf
    Homologie
    Cow,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human PPAR Gamma around the phosphorylation site of ser273
    Isotyp
    IgG
    Top Product
    Discover our top product PPARG Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Liu, Wan, Lang, Si, Zhu, Zhou, Mi: "Dihydromyricetin delays the onset of hyperglycemia and ameliorates insulin resistance without excessive weight gain in Zucker diabetic fatty rats." in: Molecular and cellular endocrinology, Vol. 439, pp. 105-115, (2018) (PubMed).

    Liu, Zhou, Lang, Zhou, Mi: "Dihydromyricetin enhances glucose uptake by inhibition of MEK/ERK pathway and consequent down-regulation of phosphorylation of PPARγ in 3T3-L1 cells." in: Journal of cellular and molecular medicine, Vol. 22, Issue 2, pp. 1247-1256, (2017) (PubMed).

    Abd Alla, Graemer, Fu, Quitterer: "Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice." in: The Journal of biological chemistry, Vol. 291, Issue 6, pp. 2583-600, (2016) (PubMed).

    Agrawal, Chanley, Westbrook, Nie, Kitao, Guess, Benndorf, Hidalgo, Smoyer: "Pioglitazone Enhances the Beneficial Effects of Glucocorticoids in Experimental Nephrotic Syndrome." in: Scientific reports, Vol. 6, pp. 24392, (2016) (PubMed).

    Maganti, Tersey, Syed, Nelson, Colvin, Maier, Mirmira: "Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice." in: The Journal of biological chemistry, Vol. 291, Issue 43, pp. 22524-22533, (2016) (PubMed).

    Stechschulte, Ge, Hinds, Sanchez, Franceschi, Lecka-Czernik et al.: "Protein Phosphatase PP5 Controls Bone Mass and the Negative Effects of Rosiglitazone on Bone through Reciprocal Regulation of PPARγ (Peroxisome Proliferator-activated Receptor γ) and RUNX2 ..." in: The Journal of biological chemistry, Vol. 291, Issue 47, pp. 24475-24486, (2016) (PubMed).

    Liu, Feng, Zhu, Liu, Han, Chen, Wang, Li, Li, Xu, Si: "Identification of a novel selective agonist of PPAR? with no promotion of adipogenesis and less inhibition of osteoblastogenesis." in: Scientific reports, Vol. 5, pp. 9530, (2015) (PubMed).

    Kolli, Stechschulte, Dowling, Rahman, Czernik, Lecka-Czernik: "Partial agonist, telmisartan, maintains PPAR? serine 112 phosphorylation, and does not affect osteoblast differentiation and bone mass." in: PLoS ONE, Vol. 9, Issue 5, pp. e96323, (2014) (PubMed).

    Pandurangan, Park, Kim: "Aspartame downregulates 3T3-L1 differentiation." in: In vitro cellular & developmental biology. Animal, Vol. 50, Issue 9, pp. 851-7, (2014) (PubMed).

    Sarr, Thompson, Zhao, Lee, Regnault: "Low birth weight male guinea pig offspring display increased visceral adiposity in early adulthood." in: PLoS ONE, Vol. 9, Issue 6, pp. e98433, (2014) (PubMed).

  • Target
    PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
    Andere Bezeichnung
    PPAR Gamma (PPARG Produkte)
    Synonyme
    PPAR gamma antikoerper, PPARg2 antikoerper, PPARG antikoerper, Nr1c3 antikoerper, PPAR-gamma antikoerper, PPAR-gamma2 antikoerper, PPARgamma antikoerper, PPARgamma2 antikoerper, NR1C3 antikoerper, CIMT1 antikoerper, GLM1 antikoerper, PPARG1 antikoerper, PPARG2 antikoerper, xPPAR-gamma antikoerper, PPAR-GAMMA antikoerper, PPARGAMMA antikoerper, peroxisome proliferator-activated receptor gamma antikoerper, peroxisome proliferator activated receptor gamma antikoerper, peroxisome proliferator activated receptor gamma L homeolog antikoerper, PPARG antikoerper, Pparg antikoerper, pparg.L antikoerper
    Hintergrund

    Synonyms: GLM1, CIMT1, NR1C3, PPARG1, PPARG2, PPARgamma, Peroxisome proliferator-activated receptor gamma, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG

    Background: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.

    Gen-ID
    5468
    UniProt
    P37231
    Pathways
    MAPK Signalweg, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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