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RAPGEF3 Antikörper (AA 301-400)

RAPGEF3 Reaktivität: Human, Ratte ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1387844
  • Target Alle RAPGEF3 Antikörper anzeigen
    RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))
    Bindungsspezifität
    • 14
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    Reaktivität
    • 55
    • 38
    • 32
    • 8
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    Human, Ratte
    Wirt
    • 53
    • 2
    Kaninchen
    Klonalität
    • 43
    • 12
    Polyklonal
    Konjugat
    • 25
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RAPGEF3 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 16
    • 12
    • 12
    • 12
    • 10
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Ratte
    Homologie
    Mouse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Epac1
    Isotyp
    IgG
    Top Product
    Discover our top product RAPGEF3 Primärantikörper
  • Applikationshinweise
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))
    Andere Bezeichnung
    Epac1 (RAPGEF3 Produkte)
    Synonyme
    RAPGEF3 antikoerper, epac antikoerper, si:dkey-27m20.2 antikoerper, CAMP-GEFI antikoerper, EPAC antikoerper, EPAC1 antikoerper, HSU79275 antikoerper, bcm910 antikoerper, 2310016P22Rik antikoerper, 9330170P05Rik antikoerper, Epac antikoerper, Epac1 antikoerper, Rap guanine nucleotide exchange factor 3 antikoerper, Rap guanine nucleotide exchange factor 3 S homeolog antikoerper, Rap guanine nucleotide exchange factor (GEF) 3 antikoerper, RAPGEF3 antikoerper, rapgef3.S antikoerper, rapgef3 antikoerper, Rapgef3 antikoerper
    Hintergrund

    Synonyms: bcm910, CAMP GEFI, cAMP regulated guanine nucleotide exchange factor I, CAMPGEFI, CGEF 1, CGEF1, EPA1, Epac 1, EPAC, EPAC1, Exchange factor directly activated by cAMP 1, Exchange protein directly activated by cAMP 1, MGC21410, RAP guanine nucleotide exchange factor, Rap guanine nucleotide exchange factor GEF 3, RAP guanine nucleotide exchange factor 3, Rap1 guanine nucleotide exchange factor directly activated by cAMP, RAPGEF3.

    Background: The activation of RaP1 by cAMP is independent of PKA and is mediated by recently discovered family of guanine nucleotide exchange factors (GEFs) called cAMP-GEFs or Epacs. The Epac signaling therefore represents a novel mechanism for cAMP signaling with in the cAMP cascade. There are 2 members of the Epac family, Epac1 and Epac 2. Both proteins are multidomain proteins containing an autoinhibitory cAMP-binding domain that inhibits the catalytic region and a DEP domain (dishevelled, Egl-10 and pleckstrin homology domain) targeting the membrane anchors. EPAC2 has an additional cAMP-binding site in its N-terminus that binds cAMP with low affinity. EPAC1 mRNA is broadly expressed, with particularly high levels occurring in the thyroid, ovary, kidney and certain brain regions, whereas expression of EPAC2 mRNA appears to be restricted to the brain and adrenal glands. Epac 1 and Epac 2 also interact with light chain 2 (LC2) or MAP1A that serves as a scaffolding structure to stabilize the signal transduction complex. The Epac 1-selective were generated against unique antigenic sequences form near N-terminus and between RasGEFN and Ras GEF domains. The to Epac 1are affinity purified over immobilized antigen based chromatography.

    Gen-ID
    1019
    Pathways
    cAMP Metabolic Process
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