O3FAR1 Antikörper (AA 21-120)

Produktnummer ABIN1387736

Produktdetails anti-O3FAR1 Antikörper

Target: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Bindungsspezifität: AA 21-120

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser O3FAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human G protein coupled receptor 120

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-O3FAR1 Antikörper (ABIN1387736)

Meng, Yuan, Zhang, Zhang, Fu, Zhu, Shu, Wang, Gao, Xi, Sun, Zhang, Jiang, Wang: "Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice." in: Biochemical and biophysical research communications, Vol. 491, Issue 1, pp. 192-197, (2017) (PubMed).

Details zu O3FAR1

Target: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Andere Bezeichnung: GPR120 (O3FAR1 Produkte)

Synonyme: BMIQ10 antikoerper, GPR120 antikoerper, GPR129 antikoerper, GT01 antikoerper, O3FAR1 antikoerper, PGR4 antikoerper, AI552415 antikoerper, Gpr120 antikoerper, Gpr129 antikoerper, KPG_013 antikoerper, O3far1 antikoerper, Pgr4 antikoerper, free fatty acid receptor 4 antikoerper, phosphodiesterase 6C antikoerper, FFAR4 antikoerper, Ffar4 antikoerper, PDE6C antikoerper

Hintergrund:

Synonyms: G protein coupled receptor 120, GPCR GPR120, G protein coupled receptor 129, G protein coupled receptor GT01, G protein coupled receptor PGR 4, G protein coupled receptor PGR4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, GPR 120, GPR 129, GPR120, GPR129, GT01, HGNC:19345, MGC119984, O3FA1_HUMAN, O3FAR1, Omega-3 fatty acid receptor 1, PGR 4, PGR4, GPCR120.

Background: GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes.

Gen-ID: 338557

UniProt: Q5NUL3

Pathways: Hormone Transport