IL28RA Antikörper (AA 51-150)

Produktnummer ABIN1387718

Produktdetails anti-IL28RA Antikörper

Target: IL28RA (Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA))

Bindungsspezifität: AA 51-150

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL28RA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Spezifität: Predicted to also work in Rat based on sequence similarity

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-28R

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-IL28RA Antikörper (ABIN1387718)

McGuire, Frieling, Lo, Li, Muhammad, Lawrence, Lawrence, Cook, Lynch: "Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer." in: Nature communications, Vol. 12, Issue 1, pp. 723, (2021) (PubMed).

Details zu IL28RA

Target: IL28RA (Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA))

Andere Bezeichnung: IL-28R (IL28RA Produkte)

Synonyme: IFNLR1 antikoerper, IL28RA antikoerper, crf2/12 antikoerper, ifnlr antikoerper, il-28r1 antikoerper, il28ra antikoerper, licr2 antikoerper, ifnlr1 antikoerper, CRF2-12 antikoerper, Il28ra antikoerper, CRF2/12 antikoerper, IFNLR antikoerper, IL-28R1 antikoerper, LICR2 antikoerper, RGD1562689 antikoerper, interferon lambda receptor 1 antikoerper, interferon, lambda receptor 1 antikoerper, interferon, lambda receptor 1 L homeolog antikoerper, IFNLR1 antikoerper, ifnlr1 antikoerper, ifnlr1.L antikoerper, Ifnlr1 antikoerper

Hintergrund:

Synonyms: IFNLR, LICR2, IL28RA, CRF2/12, IL-28R1, Interferon lambda receptor 1, IFN-lambda receptor 1, IFN-lambda-R1, Cytokine receptor class-II member 12, Cytokine receptor family 2 member 12, CRF2-12, Interleukin-28 receptor subunit alpha, IL-28 receptor subunit alpha, IL-28R-alpha, IL-28RA, Likely interleukin or cytokine receptor 2, IFNLR1

Background: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Gen-ID: 163702

UniProt: Q8IU57