DEPTOR Antikörper (DEP Domain Containing MTOR-Interacting Protein) (AA 62-107)

Details for Product anti-DEPTOR Antibody No. ABIN1387597, Anbieter: Anmelden zum Anzeigen
Antigen
  • DEP.6
  • DEPDC6
  • 4731402B04Rik
  • 9130412E02Rik
  • D15Ertd336e
  • D15Ertd597e
  • Depdc6
  • Depdc6-001
  • Depdc6-002
  • R75183
  • mKIAA4200
  • RGD1561030
  • RAPGEF4
  • DEP domain containing MTOR interacting protein
  • DEP domain containing MTOR-interacting protein
  • DEPTOR
  • Deptor
Epitop
AA 62-107
16
14
14
8
4
3
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
69
40
15
7
4
4
2
2
2
2
2
2
2
1
Wirt
Kaninchen
60
8
1
Klonalität
Polyklonal
Konjugat
Dieser DEPTOR Antikörper ist unkonjugiert
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
52
22
21
15
15
14
12
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen KLH conjugated synthetic peptide derived from human DEPTOR/DEPDC6
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere DEPTOR products on genomics-online (e.g. as negative or positive controls)
Antigen DEP Domain Containing MTOR-Interacting Protein (DEPTOR)
Andere Bezeichnung Deptor (DEPTOR Antibody Abstract)
Hintergrund

DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

Synonyms: DEP.6, DEPDC6, DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6, DEPTOR

Gen-ID 64798
UniProt Q8TB45
Pathways PI3K-Akt Signalweg, RTK Signalweg, Regulation of Cell Size
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-DEP Domain Containing MTOR-Interacting Protein (DEPTOR) (AA 62-107) antibody (ABIN1387597) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti DEPTOR/D...
Immunohistochemistry (IHC) image for anti-DEP Domain Containing MTOR-Interacting Protein (DEPTOR) (AA 62-107) antibody (ABIN1387597) Formalin-fixed and paraffin embedded rat liver labeled with Anti DEPTOR/DEPDC6 Polycl...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-DEP Domain Containing MTOR-Interacting Protein (DEPTOR) (AA 62-107) antibody (ABIN1387597) Paraformaldehyde-fixed, paraffin embedded rat brain, Antigen retrieval by boiling in ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-DEP Domain Containing MTOR-Interacting Protein (DEPTOR) (AA 62-107) antibody (ABIN1387597) Paraformaldehyde-fixed, paraffin embedded human colon cancer, Antigen retrieval by bo...
Produkt verwendet in: Liu, Zhang, Liu, Li, Zhang, Li, Liu, Huang, Shen, Gu, Gao, Wu, Wu: "High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma." in: OncoTargets and therapy, Vol. 8, pp. 3449-55, 2015 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Human).

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