ZNRF3 Antikörper (AA 120-165)

Produktnummer ABIN1386947

Produktdetails anti-ZNRF3 Antikörper

Target: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Bindungsspezifität: AA 120-165

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNRF3 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZNRF3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu ZNRF3

Target: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Andere Bezeichnung: ZNRF3 (ZNRF3 Produkte)

Synonyme: BK747E2.3 antikoerper, RNF203 antikoerper, AA591877 antikoerper, BC019575 antikoerper, Gm1167 antikoerper, zinc and ring finger 3 antikoerper, Znrf3 antikoerper, ZNRF3 antikoerper

Hintergrund:

Synonyms: RNF203, BK747E2.3, E3 ubiquitin-protein ligase ZNRF3, RING finger protein 203, Zinc/RING finger protein 3, ZNRF3, KIAA1133

Background: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Gen-ID: 84133

UniProt: Q9ULT6

Pathways: WNT Signalweg