SLC25A12 Antikörper (AA 101-200)

Produktnummer ABIN1385908

Produktdetails anti-SLC25A12 Antikörper

Target: SLC25A12 (Slc25a12) (Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12))

Bindungsspezifität: AA 101-200

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC25A12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SLC25A12/ARALAR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu SLC25A12

Target: SLC25A12 (Slc25a12) (Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12))

Andere Bezeichnung: SLC25A12/ARALAR (Slc25a12 Produkte)

Synonyme: cb929 antikoerper, cb1094 antikoerper, zgc:66248 antikoerper, wu:fj94c07 antikoerper, AGC1 antikoerper, ARALAR antikoerper, Aralar1 antikoerper, RGD1561141 antikoerper, ARALAR1 antikoerper, 2610002D09Rik antikoerper, AI839531 antikoerper, B230107K20Rik antikoerper, BB129864 antikoerper, solute carrier family 25 (aspartate/glutamate carrier), member 12 antikoerper, solute carrier family 25 member 12 antikoerper, solute carrier family 25 member 12 L homeolog antikoerper, solute carrier family 25 (mitochondrial carrier, Aralar), member 12 antikoerper, slc25a12 antikoerper, SLC25A12 antikoerper, slc25a12.L antikoerper, Slc25a12 antikoerper

Hintergrund:

Synonyms: AGC1, Araceli hiperlarga, ARALAR, ARALAR1, Calcium binding mitochondrial carrier superfamily member, Calcium-binding mitochondrial carrier protein Aralar1, CMC1_HUMAN, Mitochondrial aspartate glutamate carrier 1, SLC25A12, Solute carrier family 25 member 12, solute carrier family 25, member 12.

Background: Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.

Pathways: Ribonucleoside Biosynthetic Process, Dicarboxylic Acid Transport