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COPS7B Antikörper (AA 201-264)

COPS7B Reaktivität: Human WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1385881
  • Target Alle COPS7B Antikörper anzeigen
    COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))
    Bindungsspezifität
    • 14
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 201-264
    Reaktivität
    • 26
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 24
    • 2
    Kaninchen
    Klonalität
    • 26
    Polyklonal
    Konjugat
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser COPS7B Antikörper ist unkonjugiert
    Applikation
    • 22
    • 12
    • 12
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CSN7b
    Isotyp
    IgG
    Top Product
    Discover our top product COPS7B Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))
    Andere Bezeichnung
    CSN7b (COPS7B Produkte)
    Synonyme
    MGC114836 antikoerper, D1Wsu66e antikoerper, E130114M23 antikoerper, CSN7B antikoerper, COP9 signalosome subunit 7B antikoerper, COP9 signalosome subunit 7B S homeolog antikoerper, Cops7b antikoerper, COPS7B antikoerper, cops7b.S antikoerper
    Hintergrund

    Synonyms: COP9 Complex Homolog Subunit 7b; COP9 Constitutive Photomorphogenic Homolog Subunit 7b; COP9 Signalasome Subunit 7b; COP9 signalosome complex subunit 7b; COPS7B; CSN7B_HUMAN; JAB1 Containing Signalosome Subunit 7b; JAB1-containing signalosome subunit 7b; SGN7b; Signalosome subunit 7b.

    Background: The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I˚Bå and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.

    Pathways
    Zellzyklus
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