COPS6 Antikörper

Produktnummer ABIN1385605

Produktdetails anti-COPS6 Antikörper

Target: COPS6 (COP9 Signalosome Complex Subunit 6 (COPS6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COPS6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu COPS6

Target: COPS6 (COP9 Signalosome Complex Subunit 6 (COPS6))

Andere Bezeichnung: COPS6 (COPS6 Produkte)

Synonyme: CG6932 antikoerper, CH6 antikoerper, Csn6 antikoerper, Dch6 antikoerper, Dmel\\CG6932 antikoerper, zgc:112075 antikoerper, Sgn3 antikoerper, VIP/MOV34 antikoerper, CSN6 antikoerper, MOV34-34KD antikoerper, COP9 signalosome subunit 6 antikoerper, COP-9 SigNalosome subunit antikoerper, COPS6 antikoerper, Cops6 antikoerper, CSN6 antikoerper, cops6 antikoerper, csn-6 antikoerper

Hintergrund:

Synonyms: JAB1 containing signalosome subunit 6,COP9 subunit 6 MOV34 homolog, 34 kD,MOV34 homolog, 34 kD,COP9 constitutive photomorphogenic, subunit 6, COP9 complex S6,COP9 signalosome complex subunit 6,COP9 signalosome subunit 6,cops6,CSN6,CSN6_HUMAN,hVIP,JAB1-containing signalosome subunit 6,MOV34 homolog,MOV34-34KD,Sgn3,SGN6,Signalosome subunit 6,VIP/MOV34,Vpr interacting protein,Vpr-interacting protein.

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

Gen-ID: 10980

Pathways: Zellzyklus