NMDAR3A + 3B Antikörper (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 3A/B) AA 801-900

Produktnummer ABIN1385228

Produktdetails anti-NMDAR3A + 3B Antikörper

Target: NMDAR3A + 3B (GRIN3A/B)

Bindungsspezifität: AA 801-900

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMDAR3A + 3B Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Homologie: Human,Mouse,Rat,Dog,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NMDAR3A + 3B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu NMDAR3A + 3B

Target: NMDAR3A + 3B (GRIN3A/B)

Andere Bezeichnung: NMDAR3A + 3B (GRIN3A/B Produkte)

Hintergrund:

Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neuro-degeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to 7. The kainate/AMPA receptors are primarily responsible for fast excitatory neurotransmission by glutamate, whereas the NMDA receptors exhibit slow kinesis of Ca2+ ions and a high permeability for Ca2+ ions. One such NMDA receptor, NR3B, is expressed in motor neurons and forms cation channels impermeable to calcium, which can resist many open-channel blockers. NR3B functions in the brain as an excitatory glycine receptor, modifying the normal role of glycine as an inhibitory neurotransmitter.

Subcellular location: Cytoplasm, Cell membrane

Synonyms: Glutamate Receptor Ionotropic N methyl D aspartate 3A, Glutamate Receptor Ionotropic N methyl D aspartate 3B, Glutamate Receptor Ionotropic N-methyl-D-aspartate 3A, Glutamate Receptor Ionotropic N-methyl-D-aspartate 3B, GRIN3A, GRIN3B, NMDA receptor subunit 3A, NMDA receptor subunit 3B, NMDA Type Glutamate Receptor Subunit NR3B Precursor, NMDAR-L, NR3A, NR3B, NMD3B_HUMAN_ NMD3A_HUMAN