TNFRSF8 Antikörper

Produktnummer ABIN135189

Zitiert in 1 Publikation. Der Hamster Monoklonal anti-TNFRSF8 Antikörper (Klon mCD30-1) (ABIN135189) detektiert spezifisch TNFRSF8 in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für TNFRSF8 Antikörper (ABIN135189)

Target: TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))

Reaktivität: Maus

Wirt: Hamster

Klonalität: Monoklonal

Konjugat: Dieser TNFRSF8 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: MCD30-1

Produktdetails anti-TNFRSF8 Antikörper

Spezifität: Mouse CD30, Mr 105-120 kDa

Produktmerkmale: Hamster Anti-Mouse CD30-UNLB

Aufreinigung: Purified

Immunogen: Mouse CD30-mouse IgG1 fusion protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

• Applications: FC - Quality tested , Stim - Reported in literature , Costim - Reported in literature , Block - Reported in literature
• Working Dilutions: Flow Cytometry Purified (UNLB) antibody 3 g/106 cells FITC and BIOT conjugates 3 g/106 cells PE conjugate 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Kommentare:

In vitro functional studies

Probenmenge: 1 mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Konservierungsmittel: Without preservative

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C

Referenzen für anti-TNFRSF8 Antikörper (ABIN135189)

Gur-Cohen, Itkin, Chakrabarty, Graf, Kollet, Ludin, Golan, Kalinkovich, Ledergor, Wong, Niemeyer, Porat, Erez, Sagi, Esmon, Ruf, Lapidot: "PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells." in: Nature medicine, Vol. 21, Issue 11, pp. 1307-17, (2016) (PubMed).

Details zu TNFRSF8

Target: TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))

Andere Bezeichnung: CD30

Hintergrund: CD30 is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily of proteins. Murine CD30 is expressed predominantly in the thymus, and it is inducible in mouse splenocytes stimulated with pokeweed mitogen or concanavalin A. In anti-CD3-activated spleen cells, CD30 is expressed primarily on the surface of CD8+ T cells with peak expression on days 4 and 5. Stimulation of CD30+ CTL lines with plate-bound anti-CD30 directly signals IL-5 but not IFN-γ production. While these studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 may play a pivotal role in the pattern of cytokine production by T cells, the precise roles of CD30 and its ligand (CD153) in T-cell development have not been clearly defined.