BAX Antikörper (AA 3-16)
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- Target Alle BAX Antikörper anzeigen
- BAX (BCL2-Associated X Protein (BAX))
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Bindungsspezifität
- AA 3-16
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Reaktivität
- Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser BAX Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- Spezifität
- Mouse Bax
- Produktmerkmale
- Mouse Anti-Mouse Bax-UNLB
- Aufreinigung
- Purified
- Immunogen
- Murine Bax peptide (a.a. 3-16)
- Klon
- 5B7
- Isotyp
- IgG1
- Top Product
- Discover our top product BAX Primärantikörper
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- Applikationshinweise
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Working Dilution:
Western Blotting: 1 µg/mL
Representative data are included in this product insert.
Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. - Probenmenge
- 1 mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- Product is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.
- Handhabung
- Each reagent is stable for the period shown on the bottle label if stored as directed.
- Lagerung
- 4 °C
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- Target
- BAX (BCL2-Associated X Protein (BAX))
- Andere Bezeichnung
- Bax (BAX Produkte)
- Synonyme
- BAX-ALPHA antikoerper, bax-A antikoerper, xBax antikoerper, xlbax antikoerper, BAX antikoerper, bax antikoerper, fj16e01 antikoerper, wu:fc50b10 antikoerper, wu:fj16e01 antikoerper, BCL2L4 antikoerper, zgc:112983 antikoerper, BCL2 associated X, apoptosis regulator antikoerper, BCL2-associated X protein L homeolog antikoerper, BCL2-associated X protein antikoerper, bcl2-associated X protein, a antikoerper, bcl2-associated X protein, b antikoerper, BAX antikoerper, bax.L antikoerper, bax antikoerper, baxa antikoerper, Bax antikoerper, baxb antikoerper
- Hintergrund
- Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bax is a member of the Bcl-2 family of apoptosis-associated proteins and, although it is similar in structure to Bcl-2, Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial membranes, inducing mitochondrial damage and subsequent cell death in a caspase-independent manner, presumably via their ion channel-forming activity. These channels may then function to promote a mitochondrial permeability transition or to puncture the outer mitochondrial membrane. In addition to forming homodimer, Bax can heterodimerize with Bcl-2 and Bcl-XL proteins. This heterodimerization between pro- and anti-apoptotic family members may serve a titration function and act as a sensor for the programmed cell death program. Mab 5B7 is specific for mouse Bax.
- Pathways
- p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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