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SCN9A Antikörper (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit) Primary Antibody

SCN9A Reaktivität: Human, Maus, Ratte ISt, IHC Wirt: Maus Monoclonal N68-6 unconjugated
Pubmed (16 references)
Produktnummer ABIN1304843
$533.50
Zzgl. Versandkosten $45.00
5 mL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 2 bis 6 Werktagen
  • Target Alle SCN9A Antikörper anzeigen
    SCN9A
    Reaktivität
    • 51
    • 29
    • 25
    • 11
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 28
    • 18
    • 7
    • 1
    Maus
    Klonalität
    • 36
    • 18
    Monoklonal
    Konjugat
    • 26
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SCN9A Antikörper ist unkonjugiert
    Applikation
    • 32
    • 20
    • 15
    • 14
    • 13
    • 12
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunostaining (ISt), Immunohistochemistry (IHC)
    Produktmerkmale
    Na+ channels
    Aufreinigung
    TC Supernatant: Hybridoma tissue-culture supernatant (5mL) containing 20-40 µg/mL monoclonal antibody (mAb).
    Immunogen
    Fusion protein amino acids 1751-1946 (cytoplasmic C-terminus) of human Nav1.7 (also known as sodium channel protein type 9 subunit alpha, neuroendocrine sodium channel, hNE-Na and peripheral sodium channel 1, accession number Q15858)
    Klon
    N68-6
    Isotyp
    IgG1
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
  • Vandael, Ottaviani, Legros, Lefort, Guérineau, Allio, Carabelli, Carbone: "Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells." in: The Journal of physiology, Vol. 593, Issue 4, pp. 905-27, (2015) (PubMed).

    Lu, Ikeda, Puhl: "A 3.7 kb fragment of the mouse Scn10a gene promoter directs neural crest but not placodal lineage EGFP expression in a transgenic animal." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 20, pp. 8021-34, (2015) (PubMed).

    Eom, Zhang, Wang, Lay, Fak, Noebels, Darnell: "NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure." in: eLife, Vol. 2, pp. e00178, (2013) (PubMed).

    Melemedjian, Khoutorsky, Sorge, Yan, Asiedu, Valdez, Ghosh, Dussor, Mogil, Sonenberg, Price: "mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK." in: Pain, Vol. 154, Issue 7, pp. 1080-91, (2013) (PubMed).

    Liang, Fan, Tao, Yaster, Tao: "Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons." in: The journal of pain : official journal of the American Pain Society, Vol. 14, Issue 6, pp. 638-47, (2013) (PubMed).

    Dustrude, Wilson, Ju, Xiao, Khanna: "CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking." in: The Journal of biological chemistry, Vol. 288, Issue 34, pp. 24316-31, (2013) (PubMed).

    Campbell, Main, Fitzgerald: "Functional expression of the voltage-gated Na?-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells." in: Journal of cell science, Vol. 126, Issue Pt 21, pp. 4939-49, (2013) (PubMed).

    Laedermann, Syam, Pertin, Decosterd, Abriel: "?1- and ?3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells." in: Frontiers in cellular neuroscience, Vol. 7, pp. 137, (2013) (PubMed).

    Yan, Melemedjian, Price, Dussor: "Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6)." in: Molecular pain, Vol. 8, pp. 6, (2012) (PubMed).

    Ho, Zhao, Malinowski, Chahine, OLeary: "Differential expression of sodium channel ? subunits in dorsal root ganglion sensory neurons." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15044-53, (2012) (PubMed).

    Cachemaille, Laedermann, Pertin, Abriel, Gosselin, Decosterd: "Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain." in: Neuroscience, Vol. 227, pp. 370-80, (2012) (PubMed).

    Liu, Tu, Zhang, Zheng, Li: "Voltage-gated sodium channel expression and action potential generation in differentiated NG108-15 cells." in: BMC neuroscience, Vol. 13, pp. 129, (2012) (PubMed).

    Chattopadhyay, Mata, Fink: "Vector-mediated release of GABA attenuates pain-related behaviors and reduces Na(V)1.7 in DRG neurons." in: European journal of pain (London, England), Vol. 15, Issue 9, pp. 913-20, (2011) (PubMed).

    Tappe-Theodor, Constantin, Tegeder, Lechner, Langeslag, Lepcynzsky, Wirotanseng, Kurejova, Agarwal, Nagy, Todd, Wettschureck, Offermanns, Kress, Lewin, Kuner: "Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization." in: Pain, Vol. 153, Issue 1, pp. 184-96, (2011) (PubMed).

    Cox, Sheynin, Shorer, Reimann, Nicholas, Zubovic, Baralle, Wraige, Manor, Levy, Woods, Parvari: "Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations." in: Human mutation, Vol. 31, Issue 9, pp. E1670-86, (2010) (PubMed).

    Ernst, Aguilar-Bryan, Noebels: "Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion." in: Endocrinology, Vol. 150, Issue 3, pp. 1132-9, (2009) (PubMed).

  • Target
    SCN9A
    Andere Bezeichnung
    Nav1.7 (SCN9A Produkte)
    Synonyme
    SCN9A, DKFZp459G084, Nav1.7, PN1, mKIAA4197, Scn2a, ETHA, FEB3B, GEFSP7, NE-NA, NENA, SFNP, sodium channel, voltage-gated, type IX, alpha subunit, sodium voltage-gated channel alpha subunit 9, sodium channel protein type 9 subunit alpha, sodium channel, voltage-gated, type IX, alpha, SCN9A, LOC100016648, Scn9a
    UniProt
    Q15858
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