SCN1A Antikörper (Sodium Channel, Voltage-Gated, Type I, alpha Subunit)

Produktnummer ABIN1304837

Produktdetails anti-SCN1A Antikörper

Target: SCN1A

Reaktivität: Säugetier

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SCN1A Antikörper ist unkonjugiert

Applikation: Immunostaining (ISt), Immunohistochemistry (IHC), Western Blotting (WB)

Produktmerkmale: Na+ channels

Aufreinigung: TC Supernatant: Hybridoma tissue-culture supernatant (5mL) containing 20-40 µg/mL monoclonal antibody (mAb).

Klon: K74-71

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Referenzen für anti-SCN1A Antikörper (ABIN1304837)

Wimmer, Harty, Richards, Phillips, Miyazaki, Nukina, Petrou: "Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain." in: The Journal of comparative neurology, Vol. 523, Issue 5, pp. 814-30, (2015) (PubMed).

Freeman, Desmazières, Simonnet, Gatta, Pfeiffer, Aigrot, Rappeneau, Guerreiro, Michel, Yanagawa, Barbin, Brophy, Fricker, Lubetzki, Sol-Foulon: "Acceleration of conduction velocity linked to clustering of nodal components precedes myelination." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 3, pp. E321-8, (2015) (PubMed).

Tian, Wang, Ke, Guo, Shu: "Molecular identity of axonal sodium channels in human cortical pyramidal cells." in: Frontiers in cellular neuroscience, Vol. 8, pp. 297, (2014) (PubMed).

Li, Tian, Scalmani, Frassoni, Mantegazza, Wang, Yang, Wu, Shu: "Action potential initiation in neocortical inhibitory interneurons." in: PLoS biology, Vol. 12, Issue 9, pp. e1001944, (2014) (PubMed).

Papale, Makinson, Christopher Ehlen, Tufik, Decker, Paul, Escayg: "Altered sleep regulation in a mouse model of SCN1A-derived genetic epilepsy with febrile seizures plus (GEFS+)." in: Epilepsia, Vol. 54, Issue 4, pp. 625-34, (2013) (PubMed).

Xiao, Bosch, Nerbonne, Ornitz: "FGF14 localization and organization of the axon initial segment." in: Molecular and cellular neurosciences, Vol. 56, pp. 393-403, (2013) (PubMed).

Vega, Avila, Matthews: "Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression." in: Scientific reports, Vol. 3, pp. 2809, (2013) (PubMed).

Puthussery, Venkataramani, Gayet-Primo, Smith, Taylor: "NaV1.1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 41, pp. 16045-59, (2013) (PubMed).

Wykes, Kalmbach, Eliava, Waters: "Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice." in: Neurobiology of aging, Vol. 33, Issue 8, pp. 1609-23, (2012) (PubMed).

Kim, Gersbacher, Inquimbert, Kovacs: "Reduced sodium channel Na(v)1.1 levels in BACE1-null mice." in: The Journal of biological chemistry, Vol. 286, Issue 10, pp. 8106-16, (2011) (PubMed).

Ahn, Black, Zhao, Tyrrell, Waxman, Dib-Hajj: "Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons." in: Molecular pain, Vol. 7, pp. 32, (2011) (PubMed).

Lysakowski, Gaboyard-Niay, Calin-Jageman, Chatlani, Price, Eatock: "Molecular microdomains in a sensory terminal, the vestibular calyx ending." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 27, pp. 10101-14, (2011) (PubMed).

Wu, Ivanova, Cui, Lu, Pan: "Action potential generation at an axon initial segment-like process in the axonless retinal AII amacrine cell." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 41, pp. 14654-9, (2011) (PubMed).

Kaphzan, Buffington, Jung, Rasband, Klann: "Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 48, pp. 17637-48, (2011) (PubMed).

Brackenbury, Calhoun, Chen, Miyazaki, Nukina, Oyama, Ranscht, Isom: "Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 2283-8, (2010) (PubMed).

Black, Newcombe, Waxman: "Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5." in: Brain : a journal of neurology, Vol. 133, Issue Pt 3, pp. 835-46, (2010) (PubMed).

Wimmer, Reid, So, Berkovic, Petrou: "Axon initial segment dysfunction in epilepsy." in: The Journal of physiology, Vol. 588, Issue Pt 11, pp. 1829-40, (2010) (PubMed).

Lorincz, Nusser: "Molecular identity of dendritic voltage-gated sodium channels." in: Science (New York, N.Y.), Vol. 328, Issue 5980, pp. 906-9, (2010) (PubMed).

Wimmer, Reid, Mitchell, Richards, Scaf, Leaw, Hill, Royeck, Horstmann, Cromer, Davies, Xu, Lerche, Berkovic, Beck, Petrou: "Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2661-71, (2010) (PubMed).

Persson, Black, Gasser, Cheng, Fischer, Waxman: "Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals." in: Molecular pain, Vol. 6, pp. 84, (2010) (PubMed).

OMalley, Shreiner, Chen, Huffnagle, Isom: "Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis." in: Molecular and cellular neurosciences, Vol. 40, Issue 2, pp. 143-55, (2009) (PubMed).

Lorincz, Nusser: "Cell-type-dependent molecular composition of the axon initial segment." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 53, pp. 14329-40, (2009) (PubMed).

Tobin, Joseph, Al-Kindi, Albarwani, Madden, Nemetz, Rusch, Rhee: "Loss of cerebrovascular Shaker-type K(+) channels: a shared vasodilator defect of genetic and renal hypertensive rats." in: American journal of physiology. Heart and circulatory physiology, Vol. 297, Issue 1, pp. H293-303, (2009) (PubMed).

von Reyn, Spaethling, Mesfin, Ma, Neumar, Smith, Siman, Meaney: "Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 33, pp. 10350-6, (2009) (PubMed).

Zhao, Barr, Hou, Dib-Hajj, Black, Albrecht, Petersen, Eisenberg, Wymer, Rice, Waxman: "Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain." in: Pain, Vol. 139, Issue 1, pp. 90-105, (2008) (PubMed).

Vega, Henry, Matthews: "Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a." in: Neuroscience letters, Vol. 442, Issue 1, pp. 69-73, (2008) (PubMed).

Duflocq, Le Bras, Bullier, Couraud, Davenne: "Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments." in: Molecular and cellular neurosciences, Vol. 39, Issue 2, pp. 180-92, (2008) (PubMed).

Mojumder, Wensel, Frishman: "Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina." in: Molecular vision, Vol. 14, pp. 1600-13, (2008) (PubMed).

Lopez-Santiago, Meadows, Ernst, Chen, Malhotra, McEwen, Speelman, Noebels, Maier, Lopatin, Isom: "Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals." in: Journal of molecular and cellular cardiology, Vol. 43, Issue 5, pp. 636-47, (2007) (PubMed).

Mojumder, Frishman, Otteson, Sherry: "Voltage-gated sodium channel alpha-subunits Na(v)1.1, Na(v)1.2, and Na(v)1.6 in the distal mammalian retina." in: Molecular vision, Vol. 13, pp. 2163-82, (2007) (PubMed).

Van Wart, Trimmer, Matthews: "Polarized distribution of ion channels within microdomains of the axon initial segment." in: The Journal of comparative neurology, Vol. 500, Issue 2, pp. 339-52, (2006) (PubMed).

Details zu SCN1A

Target: SCN1A

Andere Bezeichnung: Nav1.1 (SCN1A Produkte)

Synonyme: SCN9A, SCN1A, B230332M13, Nav1.1, EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, NAC1, SCN1, SMEI, sodium voltage-gated channel alpha subunit 1, sodium voltage-gated channel alpha subunit 9, sodium channel, voltage-gated, type I, alpha, SCN1A, SCN9A, Scn1a

UniProt: P04774