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ITPR1 Antikörper (Inositol 1,4,5-Trisphosphate Receptor, Type 1) AA 2680-2749 Primary Antibody

ITPR1 Reaktivität: Human, Maus, Ratte ISt, IHC, WB Wirt: Maus Monoclonal L24-18 unconjugated
Pubmed (17 references)
Produktnummer ABIN1304717
$460.17
Zzgl. Versandkosten $45.00
5 mL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 2 bis 6 Werktagen
  • Target Alle ITPR1 Antikörper anzeigen
    ITPR1
    Bindungsspezifität
    • 13
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2680-2749
    Reaktivität
    • 55
    • 46
    • 37
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 51
    • 14
    Maus
    Klonalität
    • 52
    • 14
    Monoklonal
    Konjugat
    • 38
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ITPR1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 33
    • 30
    • 25
    • 11
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunostaining (ISt), Immunohistochemistry (IHC), Western Blotting (WB)
    Produktmerkmale
    Ion channels
    Aufreinigung
    TC Supernatant: Hybridoma tissue-culture supernatant (5mL) containing 20-40 µg/mL monoclonal antibody (mAb).
    Immunogen
    Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type 1 IP3R accession number P29994)
    Human: 100% identity (70/70 amino acids)
    Mouse: 100% identity (70/70 amino acids)
    Rat type 2 IP3R: 66% identity (46/70 amino acids)
    Rat type 3 IP3R: 56% identity (39/70 amino acids)
    Klon
    L24-18
    Isotyp
    IgG1
  • Applikationshinweise
    Supernatant is suitable for most applications, including Western Blot, immunocytochemistry, immunohistochemistry, etc., and is a very economical choice compared to competitor offerings. For applications requiring higher antibody concentration or purity (such as immunoprecipitation, microinjection, or conjugation) it is recommended that you purchase the purified form of the antibody (supplied at 1mg/mL).
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
  • Fos, Becart, Canonigo Balancio, Boehning, Altman: "Association of the EF-hand and PH domains of the guanine nucleotide exchange factor SLAT with IP₃ receptor 1 promotes Ca²⁺ signaling in T cells." in: Science signaling, Vol. 7, Issue 345, pp. ra93, (2014) (PubMed).

    Dagley, White, Liao, Shi, Smyth, Orian, Emili, Purcell: "Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain." in: Proteomics, Vol. 14, Issue 2-3, pp. 241-61, (2014) (PubMed).

    Tykocki, Wu, Jackson, Watts: "Divergent signaling mechanisms for venous versus arterial contraction as revealed by endothelin-1." in: Journal of vascular surgery, (2014) (PubMed).

    Alzayady, Chandrasekhar, Yule: "Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels." in: The Journal of biological chemistry, Vol. 288, Issue 16, pp. 11122-34, (2013) (PubMed).

    Seo, Kim, Hur, Park, Cho: "Proteomic analysis of primary cultured rat cortical neurons in chemical ischemia." in: Neurochemical research, Vol. 38, Issue 8, pp. 1648-60, (2013) (PubMed).

    Abou-Saleh, Pathan, Daalis, Hubrack, Abou-Jassoum, Al-Naeimi, Rusch, Machaca: "Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility." in: The Journal of biological chemistry, Vol. 288, Issue 46, pp. 32941-51, (2013) (PubMed).

    Westcott, Goodwin, Segal, Jackson: "Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles." in: The Journal of physiology, Vol. 590, Issue Pt 8, pp. 1849-69, (2012) (PubMed).

    Adebiyi, Narayanan, Jaggar: "Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4341-8, (2011) (PubMed).

    Fang, Christian, Gorman, Cui, Huang, Tieu, Ballatori: "Neurosteroid transport by the organic solute transporter OST?-OST?." in: Journal of neurochemistry, Vol. 115, Issue 1, pp. 220-33, (2010) (PubMed).

    Zhao, Neeb, Leo, Pachuau, Adebiyi, Ouyang, Chen, Jaggar: "Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells." in: The Journal of general physiology, Vol. 136, Issue 3, pp. 283-91, (2010) (PubMed).

    Ingram, Toyoda, Wen, Buckmaster: "Prolonged infusion of inhibitors of calcineurin or L-type calcium channels does not block mossy fiber sprouting in a model of temporal lobe epilepsy." in: Epilepsia, Vol. 50, Issue 1, pp. 56-64, (2009) (PubMed).

    Tang, Guo, Wang, Chen, Bezprozvanny: "Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 5, pp. 1257-66, (2009) (PubMed).

    Kaufmann, Ferraguti, Fukazawa, Kasugai, Shigemoto, Laake, Sexton, Ruth, Wietzorrek, Knaus, Storm, Ottersen: "Large-conductance calcium-activated potassium channels in purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains." in: The Journal of comparative neurology, Vol. 515, Issue 2, pp. 215-30, (2009) (PubMed).

    Wilson, Elbatarny, Crawley, Bennett, Maurice: "Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 36, pp. 13650-5, (2008) (PubMed).

    Zhao, Adebiyi, Blaskova, Xi, Jaggar: "Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries." in: American journal of physiology. Cell physiology, Vol. 295, Issue 5, pp. C1376-84, (2008) (PubMed).

    Isakson: "Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication." in: Journal of cell science, Vol. 121, Issue Pt 21, pp. 3664-73, (2008) (PubMed).

    Chen, Tang, Tu, Nelson, Pook, Hammer, Nukina, Bezprozvanny: "Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 48, pp. 12713-24, (2008) (PubMed).

  • Target
    ITPR1
    Andere Bezeichnung
    IP3R-I (ITPR1 Produkte)
    Synonyme
    D6Pas2, ENSMUSG00000072853, Gm10429, IP3R1, InsP3R, Ip3r, Itpr-1, P400, Pcp-1, Pcp1, opt, I145TR, InsP3R1, INSP3R1, IP3R, SCA15, SCA16, SCA29, inositol 1,4,5-trisphosphate receptor type 1, inositol 1,4,5-trisphosphate receptor 1, inositol 1,4,5-trisphosphate receptor, type 1, ITPR1, Itpr1
    UniProt
    P29994
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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