PPP1R13L Antikörper (Isoform 1)

Produktnummer ABIN129682

Produktdetails anti-PPP1R13L Antikörper

Target: PPP1R13L (Protein Phosphatase 1, Regulatory Subunit 13 Like (PPP1R13L))

Bindungsspezifität: AA 780-797, Isoform 1

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP1R13L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 780-797 of human iASPP protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry and by western blot.  Specific conditions for reactivity should be optimized by the end user.  Expect bands approximately 100 kDa and 50 kDa in size corresponding to isoforms 1 and 2 respectively of iASPP protein by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-PPP1R13L Antikörper (ABIN129682)

Liu, Lu, Zhong: "ASPP--Apoptotic specific regulator of p53." in: Biochimica et biophysica acta, Vol. 1756, Issue 1, pp. 77-80, (2005) (PubMed).

Details zu PPP1R13L

Target: PPP1R13L (Protein Phosphatase 1, Regulatory Subunit 13 Like (PPP1R13L))

Abstract: PPP1R13L Produkte

Synonyme: AV260376 antikoerper, IASPP antikoerper, Nkip1 antikoerper, wa3 antikoerper, zgc:113058 antikoerper, NKIP1 antikoerper, RAI antikoerper, RAI4 antikoerper, protein phosphatase 1, regulatory (inhibitor) subunit 13 like antikoerper, protein phosphatase 1, regulatory subunit 13 like antikoerper, protein phosphatase 1 regulatory subunit 13 like antikoerper, protein phosphatase 1 regulatory subunit 13 like L homeolog antikoerper, Ppp1r13l antikoerper, ppp1r13l antikoerper, PPP1R13L antikoerper, ppp1r13l.L antikoerper

Hintergrund: ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, the third member, iASPP, functionally inactivates p53.  iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1.
Synonyms: inhibitor of apoptosis stimulating protein of p53 antibody, Inhibitor of ASPP protein antibody, NFkB interacting protein 1 antibody, NKIP1 antibody, PPP1R13B-like protein antibody

Gen-ID: 10848, 63003907

UniProt: Q8WUF5