LAT2 Antikörper (Linker For Activation of T Cells Family, Member 2) (AA 30-203)

Details for Product anti-LAT2 Antibody No. ABIN125755
Antigen
  • LAB
  • NTAL
  • WBSCR15
  • WBSCR5
  • WSCR5
  • LAT2
  • MGC139435
  • Ntal
  • Wbscr5
  • AW125574
  • Wbscr15
  • linker for activation of T-cells family member 2
  • linker for activation of T cells family, member 2
  • LAT2
  • Lat2
Epitop
AA 30-203
16
15
11
10
10
10
9
8
8
6
5
5
5
4
2
2
2
2
2
1
1
1
1
1
Reaktivität
Maus, Ratte (Rattus)
123
42
30
3
3
3
1
1
1
1
1
Wirt
Kaninchen
107
29
14
Klonalität
Polyklonal
Konjugat
Dieser LAT2 Antikörper ist unkonjugiert
8
8
6
3
3
3
2
2
2
2
2
2
Applikation
Immunocytochemistry (ICC), Western Blotting (WB)
131
43
32
29
16
13
11
6
5
3
3
2
1
Optionen
Immunogen Recombinant mouse NTAL (aa 30-203).
Spezifität The polyclonal antibody reacts with Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
Keine Kreuzreaktivität Human
Kreuzreaktivität (Details) Mouse, Rat, Other species Not tested
Reinigung Purified from rabbit serum by affinity chromatography
Reinheit > 95 % (by SDS-PAGE)
Plasmids, Primers & others Plasmide, Primers & weitere LAT2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung NTAL / LAB (LAT2 Antibody Abstract)
Hintergrund NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Pathways Fc-epsilon Rezeptor Signalübertragung
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Bilder des Herstellers
Immunocytochemistry (ICC) image for anti-Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 30-203) antibody (ABIN125755) Distribution of LAT and NTAL in separate clusters on mast cell plasma membrane sheets...
Immunocytochemistry (ICC) image for anti-Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 30-203) antibody (ABIN125755) Distribution of LAT and NTAL in separate clusters on mast cell plasma membrane sheets...
Allgemeine Veröffentlichungen Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: "LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4406-15, 2007 (PubMed).

Horejsí, Zhang, Schraven: "Transmembrane adaptor proteins: organizers of immunoreceptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 8, pp. 603-16, 2004 (PubMed).

Produkt verwendet in: Lebduska, Korb, T?mová, Heneberg, Dráber: "Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells." in: Journal of immunological methods, Vol. 328, Issue 1-2, pp. 139-51, 2007 (PubMed).

Heneberg, Lebduska, Dráberová, Korb, Dráber: "Topography of plasma membrane microdomains and its consequences for mast cell signaling." in: European journal of immunology, Vol. 36, Issue 10, pp. 2795-806, 2006 (PubMed).

Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL." in: The Journal of experimental medicine, Vol. 200, Issue 8, pp. 1001-13, 2004 (PubMed).

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