No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Konservierungsmittel
Azide free
Lagerung
4 °C
Informationen zur Lagerung
Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Shibuya, Campbell, Hannum, Yssel, Franz-Bacon, McClanahan, Kitamura, Nicholl, Sutherland, Lanier, Phillips: "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes." in: Immunity, Vol. 4, Issue 6, pp. 573-81, (1996) (PubMed).
Reacts with DNAX accessory molecule-1 (DNAM-1), a 65 kDa transmembrane glycoprotein consisting of 318 amino acid residues including two Ig-like domains. DNAM-1 is expressed on the majority of T cells, NK cells, monocytes, and a subset of B cells, but not on granulocytes or erythrocytes. It is also present on a subset of thymocytes coexpressing high density surface CD3. DNAM-1 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins. DNAM-1 is a tyrosinephosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. DX11 inhibits T- and NKcell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific T cells. Synonyms: DNAM-1