FNDC5 Antikörper

Produktnummer ABIN1169430

Produktdetails anti-FNDC5 Antikörper

Target: FNDC5 (Fibronectin Type III Domain Containing 5 (FNDC5))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FNDC5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Recognizes human, mouse, rat, monkey Irisin and FNDC5. Detects endogenous mouse and human Irisin [Lit: 1-2].

Kreuzreaktivität: Human, Affe, Maus, Ratte (Rattus)

Immunogen: Recombinant irisin.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-FNDC5 Antikörper (ABIN1169430)

Wrann, White, Salogiannnis, Laznik-Bogoslavski, Wu, Ma, Lin, Greenberg, Spiegelman: "Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway." in: Cell metabolism, Vol. 18, Issue 5, pp. 649-59, (2013) (PubMed).

Details zu FNDC5

Target: FNDC5 (Fibronectin Type III Domain Containing 5 (FNDC5))

Andere Bezeichnung: Irisin (FNDC5 Produkte)

Synonyme: FRCP2 antikoerper, irisin antikoerper, 1500001L03Rik antikoerper, AI836596 antikoerper, C87088 antikoerper, PeP antikoerper, Pxp antikoerper, fndc5 antikoerper, si:dkey-264p5.1 antikoerper, zgc:158684 antikoerper, fibronectin type III domain containing 5 antikoerper, fibronectin type III domain containing 5b antikoerper, FNDC5 antikoerper, Fndc5 antikoerper, fndc5b antikoerper

Hintergrund: Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

UniProt: Q8NAU1

Pathways: Hormone Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation