TICAM1 Antikörper (Toll-Like Receptor Adaptor Molecule 1) (AA 4-31)

Details for Product anti-TICAM1 Antibody No. ABIN1169062, Anbieter: Anmelden zum Anzeigen
Antigen
  • IIAE6
  • MyD88-3
  • PRVTIRB
  • TICAM-1
  • TRIF
  • AW046014
  • AW547018
  • trif
  • toll like receptor adaptor molecule 1
  • toll-like receptor adaptor molecule 1
  • TICAM1
  • Ticam1
  • ticam1
Epitop
AA 4-31, N-Term
27
5
4
4
4
2
2
2
2
2
2
2
2
1
Reaktivität
Human
69
26
10
4
3
2
2
Wirt
Kaninchen
65
7
6
Klonalität
Polyklonal
Konjugat
Dieser TICAM1 Antikörper ist unkonjugiert
1
Applikation
Immunoprecipitation (IP), Western Blotting (WB)
74
24
18
16
8
7
7
4
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Synthetic peptide corresponding to aa 4-31 (T4GPSLPSAFDILGAAGQDKLLYLKHKLK31) of N-terminal human TRIF.
Spezifität Recognizes human TRIF.
Kreuzreaktivität Human
Andere Bezeichnung TRIF (TICAM1 Antibody Abstract)
Hintergrund TRIF is involved in innate immunity against invading pathogens. It is an adaptor used by TLR3 and TLR4 (through TICAM-2) to mediate NF-kappaB and interferon-regulatory factor (IRF) activation and to induce apoptosis. Ligand binding to TLR3 and TLR4 results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappaB and FADD respectively. TRIF is ubiquitously expressed with higher levels in liver.
UniProt Q8IUC6
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer In PBS containing 0.02 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
Haltbarkeit 12 months
Produkt verwendet in: Rebsamen, Meylan, Curran, Tschopp: "The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases." in: Cell death and differentiation, Vol. 15, Issue 11, pp. 1804-11, 2008 (PubMed).

Aksoy, Albarani, Nguyen, Laes, Ruelle, De Wit, Willems, Goldman, Goriely: "Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells." in: Blood, Vol. 109, Issue 7, pp. 2887-93, 2007 (PubMed).

Carty, Goodbody, Schröder, Stack, Moynagh, Bowie: "The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling." in: Nature immunology, Vol. 7, Issue 10, pp. 1074-81, 2006 (PubMed).

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