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CXCL12 Antikörper

CXCL12 Reaktivität: Human WB, IHC (p), EIA, Func Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN116230
  • Target Alle CXCL12 Antikörper anzeigen
    CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
    Reaktivität
    • 67
    • 23
    • 19
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 82
    • 9
    • 5
    • 2
    Kaninchen
    Klonalität
    • 85
    • 13
    Polyklonal
    Konjugat
    • 44
    • 16
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CXCL12 Antikörper ist unkonjugiert
    Applikation
    • 76
    • 38
    • 34
    • 13
    • 13
    • 11
    • 9
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Functional Studies (Func)
    Spezifität
    This antibody detects Human Stromal Cell Derived Factor-1 alpha. Other species not tested.
    Aufreinigung
    Affinity Chromatography employing immobilized Human SDF1a matrix.
    Immunogen
    Highly pure (>98%) E.coli derived recombinant Human SDF1-alpha.
    Top Product
    Discover our top product CXCL12 Primärantikörper
  • Applikationshinweise
    Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hSDF1α (100 ng/mL),a concentration of 2-4 μg/mL of this antibody is required. ELISA: Indirect: Using 100 μL/well antibody solution, a concentration of 0.5-2.0 μg/mL is required. In conjunction with compatible secondary reagents, it allows the detection of at least 0.2 -0.4 ng/well of recombinant hSDF-1α. Sandwich: Using 100 μL/well antibody solution, a concentration of 0.5 - 2.0 μg/mL isrequired. In conjunction with Biotinylated Anti-Human SDF-1α (PP1067B) as a detectionantibody, it allows the detection of at least 0.2-0.4 ng/well of recombinant hSDF-1α. Western Blot: 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limitfor recombinant hSDF-1α is 1.5-3.0 ng/lane, under either reducing or non-reducingconditions.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
    Buffer
    PBS, pH 7.2 without preservatives.
    Konservierungsmittel
    Without preservative
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should protected from light.
  • Schlaepfer, Audigé, Joller, Speck: "TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 5, pp. 2888-95, (2006) (PubMed).

  • Target
    CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
    Andere Bezeichnung
    CXCL12 / SDF1 (CXCL12 Produkte)
    Synonyme
    IRH antikoerper, PBSF antikoerper, SCYB12 antikoerper, SDF1 antikoerper, TLSF antikoerper, TPAR1 antikoerper, CINC-1 antikoerper, Gro1 antikoerper, Pbsf antikoerper, Scyb12 antikoerper, Sdf1 antikoerper, Tlsf antikoerper, Tpar1 antikoerper, Fsp antikoerper, KC antikoerper, Mgsa antikoerper, N51 antikoerper, Scyb1 antikoerper, gro antikoerper, sdf-1 antikoerper, sdf1 antikoerper, xSDF-1 antikoerper, SDF-1 antikoerper, cxcl12 antikoerper, sdf-1a antikoerper, sdf1a antikoerper, wu:fa55e10 antikoerper, wu:fc16h12 antikoerper, wu:fj84c02 antikoerper, C-X-C motif chemokine ligand 12 antikoerper, C-X-C motif chemokine ligand 1 antikoerper, chemokine (C-X-C motif) ligand 12 antikoerper, chemokine (C-X-C motif) ligand 1 antikoerper, C-X-C motif chemokine ligand 12 L homeolog antikoerper, chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) antikoerper, CXCL12 antikoerper, cxcl12 antikoerper, Cxcl1 antikoerper, Cxcl12 antikoerper, cxcl12.L antikoerper, cxcl12a antikoerper
    Hintergrund
    SDF1 alpha and 1 beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF or IL1. SDF1 alpha has been shown to be chemotactic for lymphocytes and is recently reported to be a ligand for CXCR4 (LESTR/fusin), a co-receptor for HIV1 entry into T cells. SDF-1 binding to CXCR4 inhibits HIV1 entry.Synonyms: C-X-C motif chemokine 12, IRH, Intercrine reduced in hepatomas, PBSF, Pre-B cell growth-stimulating factor, SDF1A, SDF1B, Stromal cell-derived factor 1, hIRH
    Gen-ID
    6387
    NCBI Accession
    NP_000600
    UniProt
    P48061
    Pathways
    Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
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