SLC2A4 Antikörper (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4) (C-Term)

Details for Product anti-SLC2A4 Antibody No. ABIN113521, Anbieter: Anmelden zum Anzeigen
Antigen
  • GLUT4
  • Glut-4
  • Glut4
  • glut4
  • slc2a4
  • SLC2A4
  • solute carrier family 2 member 4
  • solute carrier family 2 (facilitated glucose transporter), member 4
  • solute carrier family 2 (facilitated glucose transporter), member 4 L homeolog
  • SLC2A4
  • Slc2a4
  • GLUT4
  • slc2a4.L
Epitop
C-Term
42
24
16
11
9
7
4
4
4
4
4
4
3
3
2
2
2
2
2
1
1
1
1
1
Reaktivität
Human, Affe, Maus, Schwein, Ratte (Rattus)
218
131
99
16
15
15
6
6
5
4
3
2
2
1
1
1
1
Wirt
Kaninchen
119
108
18
5
Klonalität
Polyklonal
Konjugat
Dieser SLC2A4 Antikörper ist unkonjugiert
9
9
7
5
5
5
5
5
4
4
4
4
4
4
3
3
3
1
1
1
1
1
1
Applikation
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
210
139
99
79
47
44
39
37
18
11
3
2
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen A 12 amino acid peptide corresponding to the carboxyl terminus of the insulin regulatable glucose transporter conjugated to Keyhole Limpet Hemocyanin.
Spezifität This antibody recognizes Glucose Transporter 4 (GLUT4). It does not react with HEP G2 type Glucose Transporter in Human erythrocytes, Rat brain or other tissues that do not exhibit sensitivity to Insulin. Reacts with Monkey, Pig, Mouse and Rat.
Reinigung Affinity Chromatography.
Plasmids, Primers & others Plasmide, Primers & weitere SLC2A4 products on genomics-online (e.g. as negative or positive controls)
Andere Bezeichnung GLUT4 / SLC2A4 (SLC2A4 Antibody Abstract)
Hintergrund GLUT4 is the insulin-regulated glucose transporter found in adipose tissue and striated muscle, responsible for glucose disposal. The stimulation of glucose uptake by insulin requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.Synonyms: GLUT-4, Glucose transporter 4, Glucose transporter type 4 insulin-responsive, Solute carrier family 2 facilitated glucose transporter member 4
Gen-ID 6517
NCBI Accession NP_001033
UniProt P14672
Pathways AMPK Signaling, Carbohydrate Homeostasis, Proton Transport, Brown Fat Cell Differentiation
Applikations-hinweise Western blot. Immunoprecipitation. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: 10-20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 5.0 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (C-Term) antibody (ABIN113521) Staining of paraffin embedded human heart, demonstrating labelling of cardiac myocytes.
Allgemeine Veröffentlichungen Durante, Mustard, Park, Winder, Hardie: "Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles." in: American journal of physiology. Endocrinology and metabolism, Vol. 283, Issue 1, pp. E178-86, 2002 (PubMed).

James, Strube, Mueckler: "Molecular cloning and characterization of an insulin-regulatable glucose transporter." in: Nature, Vol. 338, Issue 6210, pp. 83-7, 1989 (PubMed).

Gangal, Magar: "Biological evaluation of crab meat (Scylla-serrata) in the rat." in: The British journal of nutrition, Vol. 21, Issue 1, pp. 1-6, 1970 (PubMed).

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