EYA3 Antikörper (Middle Region)
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- Target Alle EYA3 Antikörper anzeigen
- EYA3 (Eyes Absent Homolog 3 (EYA3))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser EYA3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Sequenz
- QSRKNMTSKN RGKRKADATS SQDSELERVF LWDLDETIII FHSLLTGSYA
- Kreuzreaktivität (Details)
- Species reactivity (expected):Mouse, Rat, DogSpecies reactivity (tested):Human
- Aufreinigung
- Purified using peptide immunoaffinity column
- Immunogen
- The immunogen for anti-EYA3 antibody: synthetic peptide directed towards the middle region of human EYA3.
- Top Product
- Discover our top product EYA3 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Rekonstitution
- Add 50 μL of distilled water to a final concentration of 1 mg/mL.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
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- Target
- EYA3 (Eyes Absent Homolog 3 (EYA3))
- Andere Bezeichnung
- EYA3 (EYA3 Produkte)
- Synonyme
- zgc:152966 antikoerper, si:ch211-195b13.2 antikoerper, Xeya3 antikoerper, MGC85199 antikoerper, EYA3 antikoerper, AI844637 antikoerper, EYA transcriptional coactivator and phosphatase 3 antikoerper, EYA transcriptional coactivator and phosphatase 3 L homeolog antikoerper, eya3 antikoerper, eya3.L antikoerper, EYA3 antikoerper, Eya3 antikoerper
- Hintergrund
- EYA3 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. This protein promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. EYA3 coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity.Synonyms: Eyes absent homolog 3
- Gen-ID
- 2140
- NCBI Accession
- NP_001981
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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