Cullin 4B Antikörper
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- Target Alle Cullin 4B (CUL4B) Antikörper anzeigen
- Cullin 4B (CUL4B)
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Reaktivität
- Human, Ratte, Zebrafisch (Danio rerio)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Cullin 4B Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects Cullin-4B.
- Kreuzreaktivität (Details)
- Species reactivity (expected):RatSpecies reactivity (tested):Human, Zebrafish
- Aufreinigung
- Immunogen affinity purified
- Immunogen
- Synthetic peptide corresponding to a sequence of human Cullin 4B .Remarks: Sequence is identical to the related rat and mouse sequence.
- Isotyp
- IgG
- Top Product
- Discover our top product CUL4B Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Rekonstitution
- 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Buffer
- 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
- Konservierungsmittel
- Sodium azide, Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Target
- Cullin 4B (CUL4B)
- Andere Bezeichnung
- Cullin-4B (CUL4B Produkte)
- Synonyme
- MRXHF2 antikoerper, MRXS15 antikoerper, MRXSC antikoerper, SFM2 antikoerper, 2700050M05Rik antikoerper, AA409770 antikoerper, CUL-4B antikoerper, mKIAA0695 antikoerper, RGD1564494 antikoerper, im:7140950 antikoerper, im:7150765 antikoerper, MGC115611 antikoerper, Tb03.1J15.620 antikoerper, sfm2 antikoerper, mrxsc antikoerper, mrxhf2 antikoerper, cullin 4B antikoerper, cullin 4B S homeolog antikoerper, CUL4B antikoerper, Cul4b antikoerper, cul4b antikoerper, cul4b.S antikoerper, Tb927.3.1290 antikoerper
- Hintergrund
- Cullin 4B/CUL4B encodes a scaffold protein that organizes a cullin-RING (really interesting new gene) ubiquitin ligase (E3) complex in ubiquitylation. The CUL4 gene encodes a protein of 913 amino acids. The cullin domain is located between amino acid residues 217 and 815 and is characterized a by C-terminal globular domain (cullin homology domain) and a series of N-terminal repeats (cullin repeats). Ohtake et al. (2007) characterize a fat-soluble ligand-dependent ubiquitin ligase complex in human cell lines, in which dioxin receptor (AhR) is integrated as a component of a novel cullin 4B ubiquitin ligase complex, CUL4B(AhR). Complex assembly and ubiquitin ligase activity of CUL4B(AhR) in vitro and in vivo are dependent on the AhR ligand. In the CUL4B(AhR) complex, ligand-activated AhR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation. Their findings uncover a function for AhR as an atypical component of the ubiquitin ligase complex and demonstrate a non-genomic signalling pathway in which fat-soluble ligands regulate target-protein-selective degradation through a ubiquitin ligase complex.Synonyms: CUL-4B, CUL4B, KIAA0695
- Gen-ID
- 8450
- NCBI Accession
- NP_001073341
- UniProt
- Q13620
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