KO Validated
CTNNB1
Reaktivität: Human
WB, IHC, IF, FACS
Wirt: Maus
Monoclonal
unconjugated
Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Rekonstitution
Restore with 1.2 % sodium acetate or neutral PBS
Konzentration
0,1 mg/mL
Buffer
1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Three catenin proteins, alpha, beta and gamma, bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. The catenin/cadherin complexes play an important role mediating cellular adhesion. Not only associated with E-cadherin, alpha-catenin was also shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, is a protein that binds with alpha-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTP associates with catenin/cadherin complexes and may regulate complex signaling.Synonyms: Beta-catenin, CTNNB, CTNNB1