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CLCN3 Antikörper (AA 98-115)

CLCN3 Reaktivität: Ratte WB, IHC, IF/ICC Wirt: Maus Monoclonal S258-5 unconjugated
Produktnummer ABIN1098197
  • Target Alle CLCN3 Antikörper anzeigen
    CLCN3 (Chloride Channel 3 (CLCN3))
    Bindungsspezifität
    • 15
    • 12
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 98-115
    Reaktivität
    • 42
    • 28
    • 27
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 43
    • 14
    Maus
    Klonalität
    • 43
    • 14
    Monoklonal
    Konjugat
    • 16
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CLCN3 Antikörper ist unkonjugiert
    Applikation
    • 49
    • 18
    • 17
    • 13
    • 13
    • 13
    • 12
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC)
    Verwendungszweck
    Anti-Chloride Channel Protein 3 Mouse Monoclonal Antibody
    Spezifität
    This antibody recognizes human, mouse, and rat Clcn3. It does not cross-react with Clcn4 or Clcn5.
    Kreuzreaktivität
    Human, Maus, Ratte
    Kreuzreaktivität (Details)
    No cross Reactivity with Cav3.2
    Aufreinigung
    Purified by Protein G affinity chromatography.
    Immunogen
    Synthetic peptide correspond- ing to aa 98-115 (cytoplasmic N-terminus) of rat Clcn3 (accession no. NP_445815.2).
    Klon
    S258-5
    Isotyp
    IgG1
    Top Product
    Discover our top product CLCN3 Primärantikörper
  • Applikationshinweise
    Immunoblotting: use at 1-2 μg/mL. A band of ~90 kDa is detected.
    Immunohistochemistry: use at 1-10 μg/mL.
    These are recommended concentrations. User should determine optimal concentrations for their application.
    Positive control: Rat brain membranes.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Rekonstitution
    Dilute in PBS or medium which is identical to that used in the assay system.
    Konzentration
    Lot specific
    Buffer
    PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    This antibody is stable for at least one (1) year at -20°C.
  • Target
    CLCN3 (Chloride Channel 3 (CLCN3))
    Andere Bezeichnung
    Chloride Channel Protein 3 (Clcn3) (CLCN3 Produkte)
    Synonyme
    CLC3 antikoerper, ClC-3 antikoerper, Clc3 antikoerper, CLCN3 antikoerper, fb78c02 antikoerper, wu:fb78c02 antikoerper, clc3 antikoerper, clc-3 antikoerper, chloride voltage-gated channel 3 antikoerper, chloride channel, voltage-sensitive 3 antikoerper, chloride channel 3 antikoerper, chloride channel protein 3 antikoerper, chloride channel, voltage-sensitive 3 S homeolog antikoerper, CLCN3 antikoerper, Clcn3 antikoerper, clcn3 antikoerper, PTRG_03131 antikoerper, BDBG_05668 antikoerper, MCYG_04420 antikoerper, clcn3.S antikoerper
    Hintergrund
    H(+)/Cl(-) exchange transporter 3,[Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {UniProtKB:P51790, PubMed:10915634}., [Isoform 2]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C (PubMed:8155321). It could help neuronal cells to establish short-term memory (PubMed:8155321). {PubMed:10915634, PubMed:8155321}.,Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Clcn3 mediates the exchange of chloride ions against protons and functions as an antiporter, contributing to the acidification of the endosome and synaptic vesicle lumen. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C.,[Isoform 1]: Lysosome membrane, Late endosome membrane, Cell membrane, Early endosome membrane,Chloride channel protein 3, ClC-3, Chloride transporter ClC-3
    NCBI Accession
    NP_445815
    UniProt
    P51792
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