Prosaposin Antikörper (AA 325-524)
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- Target Alle Prosaposin (PSAP) Antikörper anzeigen
- Prosaposin (PSAP)
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Bindungsspezifität
- AA 325-524
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Prosaposin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of human PSAP (AA: 325-524 ) expressed in E. coli.
- Klon
- 4D5F4
- Isotyp
- IgG1
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:50-1:500, FCM: 1:200 - 1:400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." in: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).
: "Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion." in: Molecular cancer, Vol. 9, pp. 30, (2010) (PubMed).
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The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." in: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).
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- Target
- Prosaposin (PSAP)
- Andere Bezeichnung
- PSAP (PSAP Produkte)
- Synonyme
- GLBA antikoerper, SAP1 antikoerper, AI037048 antikoerper, SGP-1 antikoerper, SGP1A antikoerper, cb759 antikoerper, wu:fa14a06 antikoerper, wu:fb36e02 antikoerper, wu:fb58g07 antikoerper, PSAP antikoerper, PSP-A antikoerper, SFTPA1B antikoerper, SP-A antikoerper, prosaposin antikoerper, surfactant protein A1 antikoerper, PSAP antikoerper, Psap antikoerper, psap antikoerper, LOC100011417 antikoerper, LOC100304726 antikoerper, LOC100526719 antikoerper, SFTPA1 antikoerper
- Hintergrund
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Description: This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. , ,
Aliases: GLBA, SAP1
- Molekulargewicht
- 58.1 kDa
- Gen-ID
- 5660
- HGNC
- 5660
- Pathways
- Positive Regulation of Endopeptidase Activity
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