KREMEN1 Antikörper (C-Term)

Produktnummer ABIN1077451

Produktdetails anti-KREMEN1 Antikörper

Target: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KREMEN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Three isoforms of KREMEN1 exists as a result of alternative splicing event.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal KREMEN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KREMEN1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: KREMEN1 antibody can be used for detection of KREMEN1 by Western blot at 0.5 - 1 μg/mL.

Kommentare:

(CT) Kringle-containing protein marking the eye and the nose

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Lagerung: 4 °C/-20 °C

Details zu KREMEN1

Target: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Andere Bezeichnung: KREMEN1 (KREMEN1 Produkte)

Synonyme: KREMEN1 antikoerper, krm1 antikoerper, kremen antikoerper, kremem1 antikoerper, KREMEN antikoerper, KRM1 antikoerper, AV002070 antikoerper, Kremen antikoerper, Krm1 antikoerper, si:ct737139.1 antikoerper, si:dkeyp-7c9.1 antikoerper, kringle containing transmembrane protein 1 antikoerper, kringle containing transmembrane protein 1 S homeolog antikoerper, KREMEN1 antikoerper, kremen1 antikoerper, Kremen1 antikoerper, kremen1.S antikoerper

Hintergrund: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.
Synonyms: Kringle-containing protein marking the eye and the nose, Kringle containing transmembrane protein 1, KRM1, Dickkopf receptor

Molekulargewicht: 54 kDa

Gen-ID: 83999

NCBI Accession: NP_114434

Pathways: WNT Signalweg