CRB2 Antikörper

Produktnummer ABIN1077416

Produktdetails anti-CRB2 Antikörper

Target: CRB2 (Crumbs Homolog 2 (CRB2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRB2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Spezifität: At least three isoforms of CRB2 are known to exist, this antibody will detect all three. CRB2 antibody is predicted to not cross-react with other members of the CRB family.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal CRB2 antibody was raised against a 17 amino acid peptide near the center of human CRB2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CRB2 antibody can be used for detection of CRB2 by Western blot at 1 - 2 μg/mL.

Kommentare:

(IN) Crumbs homolog 2

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Lagerung: 4 °C

Informationen zur Lagerung: CRB2 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Haltbarkeit: 12 months

Details zu CRB2

Target: CRB2 (Crumbs Homolog 2 (CRB2))

Andere Bezeichnung: CRB2 (CRB2 Produkte)

Synonyme: 5930402A21 antikoerper, BC043114 antikoerper, RGD1309368 antikoerper, crb2 antikoerper, crumbs family member 2 antikoerper, crumbs 2, cell polarity complex component antikoerper, crumbs family member 2a antikoerper, Crb2 antikoerper, CRB2 antikoerper, crb2a antikoerper

Hintergrund: CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.
Synonyms: Crumbs homolog 2, crumbs 2, crumbs-like protein 2

Molekulargewicht: 141 kDa (calculated)

Gen-ID: 286204

NCBI Accession: NP_775960

Pathways: Notch Signalweg