PPARG Antikörper (Isoform 1)

Produktnummer ABIN105800

Produktdetails anti-PPARG Antikörper

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Bindungsspezifität: AA 25-5, Isoform 1

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPARG Antikörper ist unkonjugiert

Applikation: ELISA

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 255 -268 of human PPAR gamma .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity-purified antibody has been tested for use in ELISA.  Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-PPARG Antikörper (ABIN105800)

Fei, Tamski, Cook, Santanam: "MicroRNA regulation of adipose derived stem cells in aging rats." in: PLoS ONE, Vol. 8, Issue 3, pp. e59238, (2013) (PubMed).

Moreau, Téruel, Beylot, Albalea, Tamasi, Umbdenstock, Parmentier, Sa-Cunha, Suc, Fabre, Navarro, Ramos, Meyer, Maurel, Vilarem, Pascussi: "A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte." in: Hepatology (Baltimore, Md.), Vol. 49, Issue 6, pp. 2068-79, (2009) (PubMed).

Bruedigam, Koedam, Chiba, Eijken, van Leeuwen: "Evidence for multiple peroxisome proliferator-activated receptor gamma transcripts in bone: fine-tuning by hormonal regulation and mRNA stability." in: FEBS letters, Vol. 582, Issue 11, pp. 1618-24, (2008) (PubMed).

Details zu PPARG

Target: PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))

Andere Bezeichnung: PPAR gamma 1 + 2 (PPARG Produkte)

Synonyme: PPAR gamma antikoerper, PPARg2 antikoerper, PPARG antikoerper, Nr1c3 antikoerper, PPAR-gamma antikoerper, PPAR-gamma2 antikoerper, PPARgamma antikoerper, PPARgamma2 antikoerper, NR1C3 antikoerper, CIMT1 antikoerper, GLM1 antikoerper, PPARG1 antikoerper, PPARG2 antikoerper, xPPAR-gamma antikoerper, PPAR-GAMMA antikoerper, PPARGAMMA antikoerper, peroxisome proliferator-activated receptor gamma antikoerper, peroxisome proliferator activated receptor gamma antikoerper, peroxisome proliferator activated receptor gamma L homeolog antikoerper, PPARG antikoerper, Pparg antikoerper, pparg.L antikoerper

Hintergrund: Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones.  Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma.  Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.
Synonyms: HUMPPARG antibody, NR1C3 antibody, PPAR gamma antibody, PPARG antibody, PPARG1 antibody, PPARG2 antibody

Gen-ID: 5468, 20336229

UniProt: P37231

Pathways: MAPK Signalweg, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation