SPRY2 Antikörper (Internal Region)

Produktnummer ABIN1043909

Produktdetails anti-SPRY2 Antikörper

Target: SPRY2 (Sprouty Homolog 2 (SPRY2))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPRY2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Anti-Sprouty-2 was affinity purified from monospecific antiserum by immunoaffinity chromatography. Sprouty-2 antibody reacts with human Sprouty 2 protein. A BLAST analysis was used to suggest reactivity with Sprouty 2 from human, monkey, and orangutan based on a 100% homology with the immunizing sequence. Cross-reactivity with Sprouty2 from other sources has not been determined.

Produktmerkmale: Sprouty was originally identified as an inhibitor of Drosophila epidermal growth factor (EGF) and fibroblast growth factor (FGF) receptor signaling during tracheal development. Four isoforms of mammalian sprouty are known (Spry1-Spry4). The role of the mammalian analogs has not been clearly elucidated although it is believed that human Sprouty-2 (hSpry2) may be an inhibitor of cellular migration and proliferation. Spry2 and Spry4 show considerable sequence homology between human and mouse at the C-terminus of the protein. Significant sequence divergence occurs at the N-terminus. Spry2 appears to be abundant in brain, lung and heart tissue, with lesser amounts found in kidney and skeletal muscle.

Sterilität: Sterile filtered

Immunogen: Anti-Sprouty-2 affinity purified antibody was purified from monospecific rabbit antiserum prepared via repeated immunizations with human sprouty-2 peptide.
Immunogen Type: Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Anti-Sprouty-2 antibody is suitable for ELISA, IF, and western blotting. Specific conditions for reactivity should be optimized by the end user.

Kommentare:

Gene Name: Sprouty 2

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.04 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Haltbarkeit: 12 months

Referenzen für anti-SPRY2 Antikörper (ABIN1043909)

Zhang, Chaturvedi, Jaggar, Magnuson, Lee, Patel: "Regulation of vascular smooth muscle cell proliferation and migration by human sprouty 2." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 25, Issue 3, pp. 533-8, (2005) (PubMed).

August: "Cerebrovascular and carotid artery disease." in: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Vol. 92, Issue 3, pp. 253-6, (2001) (PubMed).

Details zu SPRY2

Target: SPRY2 (Sprouty Homolog 2 (SPRY2))

Andere Bezeichnung: Sprouty-2 (SPRY2 Produkte)

Synonyme: wu:fk66h11 antikoerper, wu:fk93e11 antikoerper, zgc:110440 antikoerper, hspry2 antikoerper, xspry2 antikoerper, sprouty2 antikoerper, Xsprouty2 antikoerper, sprouty-2 antikoerper, Xtsprouty2 antikoerper, hSPRY2 antikoerper, sprouty RTK signaling antagonist 2 antikoerper, sprouty RTK signaling antagonist 2 S homeolog antikoerper, sprouty homolog 2 (Drosophila) antikoerper, spry2 antikoerper, SPRY2 antikoerper, spry2.S antikoerper, Spry2 antikoerper

Hintergrund: Sprouty was originally identified as an inhibitor of Drosophila epidermal growth factor (EGF) and fibroblast growth factor (FGF) receptor signaling during tracheal development. Four isoforms of mammalian sprouty are known (Spry1-Spry4). The role of the mammalian analogs has not been clearly elucidated although it is believed that human Sprouty-2 (hSpry2) may be an inhibitor of cellular migration and proliferation. Spry2 and Spry4 show considerable sequence homology between human and mouse at the C-terminus of the protein. Significant sequence divergence occurs at the N-terminus. Spry2 appears to be abundant in brain, lung and heart tissue, with lesser amounts found in kidney and skeletal muscle.
Synonyms: hSPRY 2, hSPRY2, MGC23039, Sprouty homolog 2 (Drosophila), Sprouty homolog 2, Sprouty2, Spry 2, sprouty-2, sprouty 2

Gen-ID: 10253

UniProt: O43597

Pathways: EGFR Signaling Pathway, Sensory Perception of Sound, EGFR Downregulation