ROBO1 Antikörper (AA 1632-1644)

Produktnummer ABIN1043879

Produktdetails anti-ROBO1 Antikörper

Target: ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))

Bindungsspezifität: AA 1632-1644

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROBO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Kreuzreaktivität: Maus, Ratte (Rattus), Hund

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1632-1644 of Human ROBO-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA , IP, immunohistochemistry, immunofluorescence, and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~181 kDa in size corresponding to ROBO-1 by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-ROBO1 Antikörper (ABIN1043879)

Li, Wang, Chen, Liang: "[Auditory neuropathy in children(analysis of 14 cases)]." in: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, Vol. 19, Issue 1, pp. 19-21, (2006) (PubMed).

Details zu ROBO1

Target: ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (ROBO1))

Andere Bezeichnung: ROBO-1 (ROBO1 Produkte)

Synonyme: DUTT1 antikoerper, SAX3 antikoerper, AW494633 antikoerper, AW742721 antikoerper, Gm310 antikoerper, ROBO1 antikoerper, dutt1 antikoerper, roundabout antikoerper, sax3 antikoerper, MGC122264 antikoerper, roundabout-1 antikoerper, roundabout guidance receptor 1 antikoerper, roundabout, axon guidance receptor, homolog 1 (Drosophila) antikoerper, roundabout guidance receptor 1 L homeolog antikoerper, ROBO1 antikoerper, Robo1 antikoerper, robo1 antikoerper, robo1.L antikoerper

Hintergrund: ROBO-1 (also called Roundabout homolog 1 precursor and Deleted in U twenty twenty (DUTT)) functions as a receptor for SLIT1 and SLIT2.  The SLIT proteins are thought to act as a molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex.  ROBO-1 may also be required for lung development. ROBO-1 is a type I membrane protein.  ROBO-1 is a widely expressed protein with the exception of the kidney.  Defects in ROBO1 may be a cause of breast and lung cancer. ROBO-1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line. Multiple splice variants have been identified for this protein.
Synonyms: ROBO-1, Roundabout homolog 1 precursor, Deleted in U twenty twenty (DUTT)

Gen-ID: 6091

UniProt: Q2M1J3

Pathways: Positive Regulation of Endopeptidase Activity