HLA-DR Antikörper
(4 Referenzen)-
- Target Alle HLA-DR Produkte
- HLA-DR
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Reaktivität
- Human, Hund, Non-Human Primate
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser HLA-DR Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Spezifität
- The mouse monoclonal antibody L243 recognizes specifically an extracellular epitope on HLA-DR molecules, both peptide-loaded and empty.
- Kreuzreaktivität (Details)
- Human, Non-Human Primates, Canine (Dog)
- Aufreinigung
- Purified by protein-A affinity chromatography.
- Reinheit
- > 95 % (by SDS-PAGE)
- Immunogen
- Human B lymphocytes
- Klon
- L243
- Isotyp
- IgG2a kappa
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anti-HLA-DR (HLA-DR) antibody (FITC)
HLA-DR Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-12 FITC
anti-HLA-DR (HLA-DR) antibodyHLA-DR Reaktivität: Human FACS, WB, IHC, ISt, StM Wirt: Maus Monoclonal TAL 1B5 unconjugated
anti-HLA-DR (HLA-DR) antibodyHLA-DR Reaktivität: Human FACS, WB, IP Wirt: Maus Monoclonal MEM-12 unconjugated
anti-HLA-DR (HLA-DR) antibody (PE)HLA-DR Reaktivität: Human, Hund, Non-Human Primate FACS Wirt: Maus Monoclonal L243 PE
anti-HLA-DR (HLA-DR) antibodyHLA-DR Reaktivität: Human FACS, WB, IHC, IF, ISt, StM Wirt: Maus Monoclonal SPM289 unconjugated
anti-HLA-DR (HLA-DR) antibodyHLA-DR Reaktivität: Human FACS, IP Wirt: Maus Monoclonal HL-39 unconjugated
anti-HLA-DR (HLA-DR) antibodyHLA-DR Reaktivität: Human, Hund, Non-Human Primate FACS, WB, IP, IHC (fro), IHC (p), ICC, Func Wirt: Maus Monoclonal L243 unconjugated
anti-HLA-DR (HLA-DR) antibody (PE)HLA-DR Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-12 PE
anti-HLA-DR (HLA-DR) antibody (APC)HLA-DR Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-12 APC
anti-HLA-DR (HLA-DR) antibody (PerCP)HLA-DR Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-12 PerCP
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- Applikationshinweise
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Do not freeze.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
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: "Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells." in: The Journal of clinical investigation, Vol. 119, Issue 8, pp. 2143-59, (2009) (PubMed).
: "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3491-6, (2008) (PubMed).
: "Lipid raft-dependent and -independent signaling through HLA-DR molecules." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7099-107, (2003) (PubMed).
: "Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 11, pp. 6149-53, (2002) (PubMed).
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: "Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells." in: The Journal of clinical investigation, Vol. 119, Issue 8, pp. 2143-59, (2009) (PubMed).
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- Target
- HLA-DR
- Andere Bezeichnung
- HLA-DR (HLA-DR Produkte)
- Hintergrund
- HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system.
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