TLR1 Antikörper (Toll-Like Receptor 1) (N-Term)

Details for Product anti-TLR1 Antibody No. ABIN1003315, Anbieter: Anmelden zum Anzeigen
Antigen
  • CD281
  • TIL
  • TIL. LPRS5
  • rsc786
  • toll like receptor 1
  • toll-like receptor 1
  • TLR1
  • Tlr1
Epitop
N-Term
25
12
11
7
6
5
5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
Reaktivität
Human, Maus
180
91
41
1
Wirt
Kaninchen
141
48
17
2
Klonalität
Polyklonal
Konjugat
Dieser TLR1 Antikörper ist unkonjugiert
18
17
17
5
5
3
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
133
78
76
52
37
14
14
13
13
12
11
7
6
3
2
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Rabbit polyclol TLR1 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human TLR1 (GenBank accession no. AAB94569).
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN1004213.
Isotyp IgG
Reinigung Ion exchange chromatography purified.
Plasmids, Primers & others Plasmide, Primers & weitere TLR1 products on genomics-online (e.g. as negative or positive controls)
Andere Bezeichnung Toll-Like Receptor 1 (TLR1 Antibody Abstract)
Hintergrund Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR1 is co-expressed with TLR2 on myeloid cells of the innate immune systems in lymphoid tissue such as monocytes and dendritic cells where they form heterodimers that can recognize triacylated lipoproteins.
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
Applikations-hinweise TLR1 antibody can be used for detection of TLR1 by Western blot at 1 to 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Lagerung 4 °C
Haltbarkeit 12 months
Allgemeine Veröffentlichungen Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Produkt verwendet in: ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, 2003 (PubMed).

Haben Sie etwas anderes gesucht?