TIRAP Antikörper (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein) (Internal Region)

Details for Product anti-TIRAP Antibody No. ABIN1003283, Anbieter: Anmelden zum Anzeigen
Antigen
  • mal
  • wyatt
  • BACTS1
  • Mal
  • MyD88-2
  • AA407980
  • C130027E04Rik
  • Tlr4ap
  • Wyatt
  • toll-interleukin 1 receptor (TIR) domain containing adaptor protein
  • TIR domain containing adaptor protein
  • toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog
  • toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
  • tirap
  • TIRAP
  • tirap.L
  • Tirap
Epitop
Internal Region
30
21
14
5
5
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human
146
69
38
2
2
2
1
1
1
1
Wirt
Kaninchen
111
31
5
5
Klonalität
Polyklonal
Konjugat
Dieser TIRAP Antikörper ist unkonjugiert
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
108
58
48
29
26
7
4
2
2
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Rabbit polyclol TIRAP antibody was raised against a peptide corresponding to amino acids near the middle of human TIRAP (GenBank accession no. AAL05627).
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN1004041.
Isotyp IgG
Reinigung Ion exchange chromatography purified.
Plasmids, Primers & others Plasmide, Primers & weitere TIRAP products on genomics-online (e.g. as negative or positive controls)
Antigen Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP)
Andere Bezeichnung TIRAP (Toll-Like Receptor Adaptor Protein) (TIRAP Antibody Abstract)
Hintergrund Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kappaB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
Applikations-hinweise TIRAP antibody can be used for detection of TIRAP by Western blot at 4 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Lagerung 4 °C
Haltbarkeit 12 months
Allgemeine Veröffentlichungen Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Produkt verwendet in: ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, 2003 (PubMed).

Haben Sie etwas anderes gesucht?