FAIM2 Antikörper (Fas Apoptotic Inhibitory Molecule 2)

Details for Product anti-FAIM2 Antibody No. ABIN1002721, Anbieter: Anmelden zum Anzeigen
Antigen
  • FAIM2
  • faim2
  • MGC84041
  • zgc:110143
  • MGC146456
  • LFG
  • LFG2
  • NGP35
  • NMP35
  • TMBIM2
  • 2900002L20Rik
  • Lfg
  • Lfg2
  • NMP25
  • Nmp35
  • Fas apoptotic inhibitory molecule 2
  • Fas apoptotic inhibitory molecule 2 L homeolog
  • Fas apoptotic inhibitory molecule 2a
  • fas apoptotic inhibitory molecule 2
  • FAIM2
  • faim2
  • faim2.L
  • faim2a
  • CpipJ_CPIJ015441
  • Faim2
Reaktivität
Human, Maus, Ratte (Rattus)
70
23
22
7
5
4
4
3
2
2
2
2
1
1
Wirt
Kaninchen
67
4
Klonalität
Polyklonal
Konjugat
Dieser FAIM2 Antikörper ist unkonjugiert
2
2
2
2
2
2
Applikation
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
66
31
19
18
3
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Rabbit polyclol LFG antibody was raised against a 16 amino acid peptide from near the amino terminus of human LFG (GenBank accession no. AAF06327).
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN2862301.
Isotyp IgG
Reinigung Affinity chromatography purified via peptide column.
Plasmids, Primers & others Plasmide, Primers & weitere FAIM2 products on genomics-online (e.g. as negative or positive controls)
Antigen Fas Apoptotic Inhibitory Molecule 2 (FAIM2)
Andere Bezeichnung LFG (FAIM2 Antibody Abstract)
Hintergrund Programmed cell death regulates a number of biological pr ocesses such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. LFG is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, LFG is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. LFG, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. LFG is widely distributed, but highly expressed in the hippocampus and other neural tissues. LFG was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.
Applikations-hinweise LFG antibody can be used for detection of LFG by Western blot at 0.5 – 1 myg/ml. (Optimal dilution should be determined by user.) EL4 cell lysate can be used as positive control. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far. LFG antibody is human, mouse and rat reactive.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Lagerung 4 °C
Haltbarkeit 12 months
Produkt verwendet in: Lockshin, Osborne, Zakeri: "Cell death in the third millennium." in: Cell death and differentiation, Vol. 7, Issue 1, pp. 2-7, 2000 (PubMed).

Somia, Schmitt, Vetter, Van Antwerp, Heinemann, Verma: "LFG: an anti-apoptotic gene that provides protection from Fas-mediated cell death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 22, pp. 12667-72, 1999 (PubMed).

Schweitzer, Taylor, Welcher, McClelland, Suter: "Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system." in: Molecular and cellular neurosciences, Vol. 11, Issue 5-6, pp. 260-73, 1998 (PubMed).

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