GRIK1 Antikörper (Glutamate Receptor, Ionotropic, Kainate 1) (Internal Region)

Details for Product anti-GRIK1 Antibody No. ABIN1002376, Anbieter: Anmelden zum Anzeigen
Antigen
  • GRIK1
  • grik1
  • fv36b03
  • wu:fv36b03
  • EAA3
  • EEA3
  • GLR5
  • GLUR5
  • GluK1
  • A830007B11Rik
  • D16Ium24
  • D16Ium24e
  • GluK5
  • Glur-5
  • Glur5
  • Glurbeta1
  • GluR5
  • glutamate ionotropic receptor kainate type subunit 1
  • glutamate receptor, ionotropic, kainate 1a
  • glutamate receptor, ionotropic, kainate 1
  • GRIK1
  • grik1a
  • Grik1
Epitop
Internal Region
26
9
5
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
75
46
35
4
3
3
2
2
2
1
1
1
1
Wirt
Kaninchen
55
19
5
2
Klonalität
Polyklonal
Konjugat
Dieser GRIK1 Antikörper ist unkonjugiert
3
3
2
1
1
1
Applikation
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
72
52
32
22
5
3
3
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Grik1 antibody was raised in rabbits against a 16 amino acid peptide near the center of the human Grik1.
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN1003948.
Isotyp IgG
Reinigung Affinity chromatography purified via peptide column.
Plasmids, Primers & others Plasmide, Primers & weitere GRIK1 products on genomics-online (e.g. as negative or positive controls)
Andere Bezeichnung Grik1 (GRIK1 Antibody Abstract)
Hintergrund Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
Pathways Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
Applikations-hinweise Grik1 antibody can be used for detection of Grik1 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Lagerung 4 °C
Haltbarkeit 12 months
Produkt verwendet in: Pinheiro, Mulle: "Kainate receptors." in: Cell and tissue research, Vol. 326, Issue 2, pp. 457-82, 2006 (PubMed).

Christensen, Paternain, Selak, Ahring, Lerma: "A mosaic of functional kainate receptors in hippocampal interneurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 41, pp. 8986-93, 2004 (PubMed).

Tanaka: "Functions of glutamate transporters in the brain." in: Neuroscience research, Vol. 37, Issue 1, pp. 15-9, 2000 (PubMed).

Bureau, Bischoff, Heinemann, Mulle: "Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 2, pp. 653-63, 1999 (PubMed).

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