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SPAK is a powerful regulator of peptide transporters PEPT1 and PEPT2
We identified for the first time a homozygous point mutation in STRADA causing PMSE. Additional bi-allelic mutations related to PMSE thus far have not been observed in Baylor approximately 6,000 consecutive clinical WES cases, supporting the rarity of this disorder.
aberrant nuclear accumulation of LKB1 (zeige STK11 Proteine) caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis
Several novel splice isoforms of STRADalpha that differentially affect the kinase activity, complex assembly, subcellular localization of LKB1 (zeige STK11 Proteine) and the activation of the LKB1 (zeige STK11 Proteine)-dependent AMPK (zeige PRKAA1 Proteine) pathway were discovered.
study describes structure of the core heterotrimeric LKB1 (zeige STK11 Proteine)-STRADalpha-MO25alpha (zeige CAB39 Proteine) complex, revealing an unusual allosteric mechanism of LKB1 (zeige STK11 Proteine) activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 (zeige STK11 Proteine) function
Identification and characterization of an LKB1 (zeige STK11 Proteine)-specific adaptor protein and substrate, STRAD. Results imply that STRAD plays a key role in regulating the tumor suppressor activities of LKB1 (zeige STK11 Proteine).
identify a multifactored mechanism to control LKB1 (zeige STK11 Proteine) localization, and they suggest that the STRADbeta-LKB1 (zeige STK11 Proteine) complex might possess unique functions in the nucleus
LKB1 (zeige STK11 Proteine) deacetylation is regulated by SIRT1 (zeige SIRT1 Proteine) and that this in turn influences its intracellular localization, association with STRAD, kinase activity, and ability to activate AMPK (zeige PRKAA1 Proteine).
STRADalpha.MO25alpha complexes containing LKB1 (zeige STK11 Proteine) variants were equally effective at phosphorylating and activating AMPK (zeige PRKAA1 Proteine), BRSK1 (zeige BRSK1 Proteine), and BRSK2 (zeige BRSK2 Proteine)
These data define a brush border induction pathway downstream of the Lkb1 (zeige STK11 Proteine)/Strad/Mo25 (zeige CAB39 Proteine) polarization complex, yet separate from other polarity events.
ATP and MO25alpha (zeige CAB39 Proteine) cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 (zeige STK11 Proteine) activation.
Quantitative PCR revealed significantly reduced LKB1 (zeige STK11 Proteine), MO25alpha (zeige CAB39 Proteine), and STRADbeta mRNA in LKB1 (zeige STK11 Proteine)(-/-) muscle. These findings demonstrate that the LKB1 (zeige STK11 Proteine)-MO25 (zeige CAB39 Proteine)-STRAD complex is the principal AMPKK in skeletal muscle.
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
protein kinase LYK5
, STE20-related kinase adapter protein alpha
, STE20-related kinase adaptor alpha
, STE20-related kinase adapter protein alpha-like
, STE20-like pseudokinase
, STRAD alpha
, serologically defined breast cancer antigen NY-BR-96
, STE20-related adapter protein