anti-Maus PRKAB2 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended PRKAB2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2) Antikörper
  • prkab2
  • MGC64365
  • PRKAB2
  • DKFZp469M1118
  • 5730553K21Rik
  • AW049591
  • BB124140
  • protein kinase, AMP-activated, beta 2 non-catalytic subunit L homeolog
  • protein kinase AMP-activated non-catalytic subunit beta 2
  • protein kinase, AMP-activated, beta 2 non-catalytic subunit
  • prkab2.L
  • PRKAB2
  • prkab2
  • Prkab2
Epitop
N-Term
22
8
4
4
3
2
2
1
1
1
1
1
1
1
Reaktivität
Human, Maus
70
30
17
4
4
4
4
3
2
1
1
1
1
Wirt
Kaninchen
48
16
6
Klonalität
Polyklonal
Konjugat
Dieser PRKAB2 Antikörper ist unkonjugiert
2
2
2
2
2
2
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
62
25
22
9
4
4
4
1
1
1
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN359114
$ 390.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN3043907 IHC (p) WB Rabbit IgG AA 56-89, N-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN4952261 IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2) Antikörper
Epitop N-Term
(22), (8), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus
(70), (30), (17), (4), (4), (4), (4), (3), (2), (1), (1), (1), (1)
Wirt Kaninchen
(48), (16), (6)
Klonalität
Polyklonal
Konjugat Dieser PRKAB2 Antikörper ist unkonjugiert
(2), (2), (2), (2), (2), (2), (1)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(62), (25), (22), (9), (4), (4), (4), (1), (1), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-PRKAB2 Antikörper

Target Details PRKAB2 Anwendungsinformationen Handhabung Referenzen für anti-PRKAB2 Antikörper (ABIN359114) Bilder
Spezifität This antibody reacts to AMPK beta 2 (PRKAB2).
Reinigung Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PRKAB2.
Isotyp Ig Fraction

Target Details PRKAB2

Produktdetails anti-PRKAB2 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-PRKAB2 Antikörper (ABIN359114) Bilder zurück nach oben
Antigen
Andere Bezeichnung AMPK beta-2 Chain / PRKAB2 (PRKAB2 Antibody Abstract)
Hintergrund The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.Synonyms: 5'-AMP-activated protein kinase subunit beta-2
Gen-ID 5565, 5874
UniProt O43741
Pathways AMPK Signaling

Anwendungsinformationen

Produktdetails anti-PRKAB2 Antikörper Target Details PRKAB2 Handhabung Referenzen für anti-PRKAB2 Antikörper (ABIN359114) Bilder zurück nach oben
Applikations-hinweise ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-PRKAB2 Antikörper Target Details PRKAB2 Anwendungsinformationen Referenzen für anti-PRKAB2 Antikörper (ABIN359114) Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Referenzen für anti-PRKAB2 Antikörper (ABIN359114)

Produktdetails anti-PRKAB2 Antikörper Target Details PRKAB2 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Minokoshi, Alquier, Furukawa, Kim, Lee, Xue, Mu, Foufelle, Ferré, Birnbaum, Stuck, Kahn: "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus." in: Nature, Vol. 428, Issue 6982, pp. 569-74, 2004

Prochazka, Farook, Ossowski, Wolford, Bogardus: "Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians." in: Molecular and cellular probes, Vol. 16, Issue 6, pp. 421-7, 2002

Park, Paulsen, Gammon, Mustard, Hardie, Winder: "Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 93, Issue 6, pp. 2081-8, 2002

Xu, Huang, Xu, Qian, Zhu, Yan, Cai, Zhang, Xiao, Qu, Liu, Huang, Cheng, Li, Du, Hu, Shen, Lu, Fu, Zhong, Xu, Gu, Huang, Zhao, Hu, Gu, Chen, Han: "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 26, pp. 15089-94, 2001

Thornton, Snowden, Carling: "Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12443-50, 1998

Bilder

Produktdetails anti-PRKAB2 Antikörper Target Details PRKAB2 Anwendungsinformationen Handhabung Referenzen für anti-PRKAB2 Antikörper (ABIN359114) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2) (N-Term) antibody (ABIN359114) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2) (N-Term) antibody (ABIN359114) The anti-PRKAB2 Pab is used in Western blot to detect PRKAB2 in mouse brain tissue ly...