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anti-Human PFKFB3 Antikörper:
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Human Polyclonal PFKFB3 Primary Antibody für IHC (p), WB - ABIN392768
Telang, Yalcin, Clem, Bucala, Lane, Eaton, Chesney: Ras transformation requires metabolic control by 6-phosphofructo-2-kinase. in Oncogene 2006
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Human Monoclonal PFKFB3 Primary Antibody für IP, ELISA - ABIN518808
Bao, Mukai, Hishiki, Kubo, Ohmura, Sugiura, Matsuura, Nagahata, Hayakawa, Yamamoto, Fukuda, Saya, Suematsu, Minamishima: Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo. in Molecular cancer research : MCR 2013
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Human Polyclonal PFKFB3 Primary Antibody für IP, WB - ABIN948248
Mendoza, Pocceschi, Kong, Leeper, Caro, Limesand, Burd: Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH. in Translational oncology 2012
Human Polyclonal PFKFB3 Primary Antibody für IF (p), IHC (p) - ABIN744728
Fu, Shi, Westaway, Jhamandas: Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity. in The Journal of biological chemistry 2015
Human Polyclonal PFKFB3 Primary Antibody für IHC (p), ELISA - ABIN544943
Chesney, Mitchell, Benigni, Bacher, Spiegel, Al-Abed, Han, Metz, Bucala: An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect. in Proceedings of the National Academy of Sciences of the United States of America 1999
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Human Polyclonal PFKFB3 Primary Antibody für WB - ABIN518807
Yamamoto, Takano, Ishiwata, Ohmura, Nagahata, Matsuura, Kamata, Sakamoto, Nakanishi, Kubo, Hishiki, Suematsu: Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway. in Nature communications 2014
Human Polyclonal PFKFB3 Primary Antibody für IHC, WB - ABIN6663023
Lv, Zhang, Zhai, Qiu, Zhang, Yao, Zhang: PFKFB3-mediated glycolysis is involved in reactive astrocyte proliferation after oxygen-glucose deprivation/reperfusion and is regulated by Cdh1. in Neurochemistry international 2016
Study identifies PFKFB3 as a critical factor in homologous recombination repair of ionizing radiation induced DNA double-strand breaks.
PI3K-Akt pathway inhibitors, Akti-1/2 and LY294002, reduced PFKFB3 gene induction by PHA, as well as Fru-2,6-P2 and lactate production. Moreover, both inhibitors blocked activation and proliferation in response to PHA, showing the importance of PI3K/Akt signaling pathway in the antigen response of T-lymphocytes.
conclude that PFKFB3 bears an oncogene-like regulatory element in lung adenocarcinoma progression
Results indicate that PFKFB3 is involved in the proliferation, migration, invasion and angiogenesis of breast cancer.
data suggesting that p53 promotes nucleotide biosynthesis in response to DNA damage by repressing the expression of the phosphofructokinase-2 (PFK2) isoform 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a rate-limiting enzyme that promotes glycolysis.
Study provides evidence that PFKFB3 overexpression occupied a dominant position in sorafenib resistance of hepatocellular carcinoma cells.
This work has uncovered a novel function of the enzymes PFKFB3 and PFKFB4 in ovarian cancer cells during mitotic arrest
PFK-2 seems to be a strategic element that links NADPH oxidase activation and glycolysis modulation, and, as such, is proposed as a potential therapeutic target in inflammatory diseases.
Data suggest that hepatic glucokinase activity is regulated by reversible binding to specific inhibitor protein glucokinase regulatory protein (GKRP) and by binding to activator proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2/FBP2); changes in glucokinase expression and activity are associated with poorly controlled type 2 diabetes and nonalcoholic fatty liver disease. [REVIEW]
PFKFB3 was a novel downstream substrate of mTOR signaling pathway as PFKFB3 level was augmented after knocking down TSC2 in THP1 and OCI-AML3 acute myeloid leukemia cells.
Taken together, our study identifies PFKFB3 as a key TGFbeta1 effector protein that mediates TGFbeta1's effect on Snail expression, invasion, and glycolysis.
we investigate the crosstalk between PFKFB3 and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR induction in HeLa cells in response to PFKFB3 knockdown
Knockdown of PFKFB3 by siRNAs significantly inhibited the proliferation and migration abilities of gastric cancer cells. Our data suggest that PFKFB3 might be a potential biomarker for gastric cancer and anti-neoplastic targeting gene.
The targeting of MCT1 and PFKFB3 regulated cell proliferation.
the novel role of PFKFB3 in induction of paclitaxel resistance by raising lactate production and activating TLR4 signaling, was characterized.
a novel role of PFKFB3 in glycolytic metabolism and ER stress of OA cartilage explants and chondrocytes
Our data suggest that chronic inflammation promotes the development of CRC by stimulating aerobic glycolysis and IL-6 is functioning, at least partly, through regulating PFKFB3 at early stage of colorectal cancer (CRC).
MicroRNA-26b inhibits osteosarcoma cell migration and invasion by down-regulating PFKFB3 expression
The expression of PFKFB3, PFKFB4, NAMPT, and TSPAN13 is strongly up-regulated in pediatric glioma.
Data indicate that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase3 (PFKFB3) and phosphofructokinase (PFK1) expression allows discrimination between induced pluripotent stem cells (iPS) and cancer stem cells (CSCs).
HG significantly increased PFKFB3 promoter transcription activity compared with LG.
The PFKFB3-driven glycolysis selectively promotes the extrinsic antiviral capacity of macrophages, via metabolically supporting the engulfment and removal of virus-infected cells.
Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells.
overexpression of PFKFB3 in HEK293 cells potentiated insulin-dependent phosphorylation of Akt and Akt substrates
Data show that inhibition of AMP-Activated kinase (AMPK) or 6-phosphofructo-2-kinase-fructose-2,6-biphosphatase 3 (PFKFB3) results in enhanced cell death in mitosis.
Shear stress-mediated repression of endothelial cell metabolism via KLF2 and PFKFB3 controls endothelial cell phenotype.
PFKFB3 is a promising target for the reduction of endothelial glycolysis and its related pathological angiogenesis
PFKFB3/iPFK2 responds to re-feeding, which in turn stimulates hypothalamic glycolysis and decreases hypothalamic AMPK phosphorylation and alters neuropeptide expression in a pattern that is associated with suppression of food intake.
High-fat diet feeding stimulates intestine 6-phosphofructo-2-kinase expression and induces intestine inflammatory response.
Study showed that endothelial cells (ECs)relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the glycolytic activator PFKFB3 in ECs impaired vessel formation.
a unique role for PFKFB3/iPFK2 in adipocytes with regard to diet-induced inflammatory responses in both adipose and liver tissues.
inducible PFKFB3 is required for increased growth, metabolic activity and is regulated through active JAK2 and STAT5.
Cooperation of adenosine with macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene.
PFKFB3/iPFK2 is critically involved in the anti-diabetic effect of PPARgamma activation
Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3.
Data show that PFKFB3(+/-) mice gained much less body weight than did wild-type littermates.
Inducible 6-phosphofructo-2-kinase expression is essential for the survival of the growing embryo.
Possible role of PFKFB-3 splice isoform in cell adaptation to hypoxic conditions.
uPFK-2 regulation is phosphoinositide 3-kinase-Akt-mtor dependent.
Synthesis and degradation of fructose 2,6-bisphosphate (By similarity).
, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase
, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
, 6PF-2-K/Fru-2,6-P2ase 3
, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme
, PFK/FBPase 3
, fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase
, inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
, renal carcinoma antigen NY-REN-56
, 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme
, inducible 6-phosphofructo-2-kinase
, 6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
, fructose-2,6-biphosphatase 3
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3-like