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anti-Human PFKFB3 Antikörper:
anti-Rat (Rattus) PFKFB3 Antikörper:
anti-Mouse (Murine) PFKFB3 Antikörper:
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Human Polyclonal PFKFB3 Primary Antibody für IHC (p), WB - ABIN392768
Telang, Yalcin, Clem, Bucala, Lane, Eaton, Chesney: Ras transformation requires metabolic control by 6-phosphofructo-2-kinase. in Oncogene 2006
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Human Monoclonal PFKFB3 Primary Antibody für IP, ELISA - ABIN518808
Bao, Mukai, Hishiki, Kubo, Ohmura, Sugiura, Matsuura, Nagahata, Hayakawa, Yamamoto, Fukuda, Saya, Suematsu, Minamishima: Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo. in Molecular cancer research : MCR 2013
Show all 3 Pubmed References
Human Polyclonal PFKFB3 Primary Antibody für IP, WB - ABIN948248
Mendoza, Pocceschi, Kong, Leeper, Caro, Limesand, Burd: Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH. in Translational oncology 2012
Human Polyclonal PFKFB3 Primary Antibody für WB - ABIN518807
Yamamoto, Takano, Ishiwata, Ohmura, Nagahata, Matsuura, Kamata, Sakamoto, Nakanishi, Kubo, Hishiki, Suematsu: Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway. in Nature communications 2014
Human Polyclonal PFKFB3 Primary Antibody für IF (p), IHC (p) - ABIN744728
Fu, Shi, Westaway, Jhamandas: Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity. in The Journal of biological chemistry 2015
Results indicate that PFKFB3 is involved in the proliferation, migration, invasion and angiogenesis of breast cancer.
data suggesting that p53 (zeige TP53 Antikörper) promotes nucleotide biosynthesis in response to DNA damage by repressing the expression of the phosphofructokinase-2 (PFK2) isoform 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a rate-limiting enzyme that promotes glycolysis.
Study provides evidence that PFKFB3 overexpression occupied a dominant position in sorafenib resistance of hepatocellular carcinoma cells.
This work has uncovered a novel function of the enzymes PFKFB3 and PFKFB4 (zeige PFKFB4 Antikörper) in ovarian cancer cells during mitotic arrest
PFK-2 seems to be a strategic element that links NADPH oxidase (zeige NOX1 Antikörper) activation and glycolysis modulation, and, as such, is proposed as a potential therapeutic target in inflammatory diseases.
Data suggest that hepatic glucokinase (zeige GCK Antikörper) activity is regulated by reversible binding to specific inhibitor protein glucokinase regulatory protein (GKRP (zeige GCKR Antikörper)) and by binding to activator proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2/FBP2 (zeige KHSRP Antikörper)); changes in glucokinase (zeige GCK Antikörper) expression and activity are associated with poorly controlled type 2 diabetes and nonalcoholic fatty liver disease. [REVIEW]
PFKFB3 was a novel downstream substrate of mTOR (zeige FRAP1 Antikörper) signaling pathway as PFKFB3 level was augmented after knocking down TSC2 (zeige TSC2 Antikörper) in THP1 (zeige GLI2 Antikörper) and OCI-AML3 (zeige RUNX2 Antikörper) acute myeloid leukemia (zeige BCL11A Antikörper) cells.
Taken together, our study identifies PFKFB3 as a key TGFbeta1 (zeige TGFB1 Antikörper) effector protein that mediates TGFbeta1 (zeige TGFB1 Antikörper)'s effect on Snail (zeige SNAI1 Antikörper) expression, invasion, and glycolysis.
we investigate the crosstalk between PFKFB3 and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR induction in HeLa cells in response to PFKFB3 knockdown
Knockdown of PFKFB3 by siRNAs significantly inhibited the proliferation and migration abilities of gastric cancer cells. Our data suggest that PFKFB3 might be a potential biomarker for gastric cancer and anti-neoplastic targeting gene.
HG significantly increased PFKFB3 promoter transcription activity compared with LG.
The PFKFB3-driven glycolysis selectively promotes the extrinsic antiviral capacity of macrophages, via metabolically supporting the engulfment and removal of virus-infected cells.
Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells.
overexpression of PFKFB3 in HEK293 cells potentiated insulin (zeige INS Antikörper)-dependent phosphorylation of Akt (zeige AKT1 Antikörper) and Akt (zeige AKT1 Antikörper) substrates
Data show that inhibition of AMP (zeige TMPRSS5 Antikörper)-Activated kinase (AMPK (zeige PRKAA1 Antikörper)) or 6-phosphofructo-2-kinase-fructose-2,6-biphosphatase 3 (PFKFB3) results in enhanced cell death in mitosis.
Shear stress-mediated repression of endothelial cell metabolism via KLF2 (zeige KLF2 Antikörper) and PFKFB3 controls endothelial cell phenotype.
PFKFB3 is a promising target for the reduction of endothelial glycolysis and its related pathological angiogenesis
PFKFB3/iPFK2 responds to re-feeding, which in turn stimulates hypothalamic glycolysis and decreases hypothalamic AMPK (zeige PRKAA1 Antikörper) phosphorylation and alters neuropeptide expression in a pattern that is associated with suppression of food intake.
High-fat diet feeding stimulates intestine 6-phosphofructo-2-kinase expression and induces intestine inflammatory response.
Study showed that endothelial cells (ECs)relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the glycolytic activator PFKFB3 in ECs impaired vessel formation.
Synthesis and degradation of fructose 2,6-bisphosphate (By similarity).
, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase
, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
, 6PF-2-K/Fru-2,6-P2ase 3
, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme
, PFK/FBPase 3
, fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase
, inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
, renal carcinoma antigen NY-REN-56
, 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme
, inducible 6-phosphofructo-2-kinase
, 6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
, fructose-2,6-biphosphatase 3
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3-like