StemRegenin 1

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Applikation
Functional Studies (Func), Activation (Act), Blocking Reagent (BR), Inhibition Assay (InhA)
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Verwendungszweck A promoter of self-renewal of hematopoietic stem cells (HSCs)
Produktmerkmale A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.
Reinheit ≥ 98 % by HPLC
Chemical Name 4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol hydrochloride; SR1
Formel C₂₄H₂₃N₅OS.HCl
Permeabilität Cell-permeable
Löslichkeit DMSO (approx. 10 mM)
Molekulargewicht 466 g/mol
CAS-Nummer 1227633-49-9
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Solid
Handhabung Protect from light and air
Lagerung -20 °C
Haltbarkeit 48 months
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 image for StemRegenin 1 (ABIN809566) StemRegenin 1